Evidence mapPaperPMID 39847465Full record

ReviewAnnual review of pharmacology and toxicology2025

Pharmacogenetics: Opportunities for the

Philip E Empey, Jason H Karnes, Julie A Johnson

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Philip E EmpeyCenter for Clinical Pharmaceutical Sciences, School of Pharmacy; and Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; email: pempey@pitt.edu.
Jason H KarnesDepartment of Pharmacy Practice and Science, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Julie A JohnsonClinical and Translational Science Institute, Colleges of Medicine and Pharmacy, The Ohio State University, Columbus, Ohio, USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUM1TR004548 · OHIO STATE UNIVERSITY · 2025 to 2025
$5.5M
Precision Medicine for All of Us Researchers Collective OT2OD036485 · UNIVERSITY OF ARIZONA · 2025 to 2025
$550k
NCATS NIH HHS UM1 TR004548NHGRI NIH HHS U01 HG007269NHLBI NIH HHS R21 HL172036NIH HHS OT2 OD002748NIH HHS OT2 OD026549NIH HHS OT2 OD026554NIH HHS OT2 OD036485
6 · The paper itself

Abstract

Pharmacogenetic variation is common and an established driver of response for many drugs. There has been tremendous progress in pharmacogenetics knowledge over the last 30 years and in clinical implementation of that knowledge over the last 15 years. But there have also been many examples where translation has stalled because of the lack of available data sets for discovery or validation research. The recent availability of data from very large cohorts with linked genetic, electronic health record, and other data promises new opportunities to advance pharmacogenetics research. This review presents the stages from pharmacogenetics discovery to widespread clinical adoption using prominent gene-drug pairs that have been implemented into clinical practice as examples. We discuss the opportunities that the

Indexed as

PharmacogeneticsElectronic Health RecordsHumansUnited Statesbiorepositoryelectronic health recordsgenomicspharmacogeneticspharmacogenomics

Identifiers

PMID39847465
PMCPMC12262141

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.