Evidence map›Paper›PMID 39847703›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

A Functional Variant

Bo Liu, Yulong Yu, Wan Qin, Li Yang, Minxiao Yi, Lingyan Xiao, Yongbiao Huang, Xiao Zhou, Shiying Yu, Yihua Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. When Autophagy Fails:American journal of respiratory cell and molecular biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Bo LiuDepartment of Oncology.
Yulong YuDepartment of Oncology.
Wan QinDepartment of Oncology.
Li YangDepartment of Hematology, and.
Minxiao YiDepartment of Oncology.
Lingyan XiaoDepartment of Oncology.
Yongbiao HuangDepartment of Oncology.
Xiao ZhouDepartment of Oncology.
Shiying YuDepartment of Oncology.
Yihua WangSchool of Biological Sciences, Faculty of Environmental and Life Sciences, and.ORCID 0000-0001-5561-0648
Cong-Yi WangThe Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, National Health Center Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang TangDepartment of Oncology.
Xianglin YuanDepartment of Oncology.

Funding

Medical Research Council MR/S025480/1National Natural Science Foundation of China 82130092Royal Society IEC\NSFC\191030
6 · The paper itself

Abstract

Radiation pneumonitis (RP) is characterized by inflammation and is associated with autophagy. However, the relationship between functional genetic variants of autophagy-related genes and RP remains unknown. In this study, we aimed to investigate whether genetic variants of genes involved in autophagy are associated with RP. Genotyping was conducted on a total of 301 patients for 13 SNPs of 5 genes in the autophagy pathway using MassArray and Sanger sequencing. Two radiation oncologists independently measured the degree of RP by chest X-ray or computed tomography. The multivariate Cox hazard analysis and multiple testing showed that

Indexed as

Autophagy-Related Protein 7Genetic Predisposition to DiseasePolymorphism, Single NucleotideRadiation PneumonitisAgedAnimalsAutophagyFemaleHumansMaleMiceMice, KnockoutMiddle AgedRisk FactorsATG7 protein, humanAutophagy-Related Protein 7ATG7autophagy pathwaylungradiation injuries

Identifiers

PMID39847703
PMCPMC12334840

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.