ArticlePlacenta2025
The expression of chromosome 19 miRNA cluster members during insulin sensitivity changes in pregnancy.
Article in Placenta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Relationships Between Regional and Ectopic Adiposity and Insulin Sensitivity in Early and Late Pregnancy.Diabetes care · 2026Article
- The placenta at term: insights from the Loke Centre for Trophoblast Research 18th Annual Meeting, 2025.Biology open · 2026Article
- Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy.Placenta · 2025Article
- The expression of chromosome 19 miRNA cluster members during insulin sensitivity changes in pregnancy.Placenta · 2025Article
- Placental mRNA and miRNA dynamics associated with lipid metabolism pathways in pregnancies affected by obesity.Frontiers in endocrinology · 2025Article
- Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy.Frontiers in endocrinology · 2025Article
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5 authors.
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Abstract
hypothesisDeclines in insulin sensitivity during pregnancy important for fetal growth are associated with impairments in skeletal muscle post-receptor insulin signaling. The primary initiator of these changes is unknown but believed to originate in the placenta. We hypothesize that placental miRNAs are associated with maternal sensitivity changes and impact insulin-sensitive mechanisms in target tissues in vitro.
methodsUsing qPCR, miRNA expression was measured in plasma in early (12-16 wk) and late (34-36 wk) gestation (N = 39) and placental tissue at term (37-41 weeks) (N = 142) collected from independent cohorts. Insulin-sensitive glucose uptake was measured in human skeletal muscle myoblasts exposed to miRNA mimics in vitro. Multi-linear and binomial regression models were generated to test for associations between miRNAs, insulin sensitivity and fetal growth outcomes, adjusting for relevant clinical variables. P < 0.05 was considered significant.
resultsPlacental expression of chromosome 19 miRNA cluster (C19MC) members was higher in patients with obesity and positively correlated with maternal HOMA-IR (Homeostatic Model Assessment for Insulin Resistance; miR-516b-5p, miR-517a-3p, miR-1283). Placental expression of miR-517a-3p was higher in offspring with high adiposity and birthweight. Plasma miR-517a-3p in early and late pregnancy was related to decreases in insulin sensitivity during pregnancy. Mimics for miR-517a-3p and miR-524-3p both impaired insulin-sensitive glucose uptake in human skeletal myocytes in vitro. DISCUSSION: Our findings based on data from two independent pregnancy cohorts and in vitro studies support a role for members of the C19 cluster of miRNAs - particularly miR-517a-3p - in physiological changes in insulin sensitivity over pregnancy, which may impact fetal growth.
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