Evidence map›Paper›PMID 39848406›Full record

ArticleKidney international2025

The role of sex and gender in acute kidney injury-consensus statements from the 33rd Acute Disease Quality Initiative.

Danielle E Soranno, Linda Awdishu, Sean M Bagshaw, David Basile, Samira Bell, Azra Bihorac, Joseph Bonventre, Alessandra Brendolan, Rolando Claure-Del Granado, David Collister and 18 more

Abstract readConsensus Statement
In one paragraph

Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Danielle E SorannoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: DSoranno@iu.edu.
Linda AwdishuDivision of Clinical Pharmacy, University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California, USA.
Sean M BagshawDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
David BasileDepartment of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Samira BellDivision of Population Health and Genomics, University of Dundee, Dundee, UK.
Azra BihoracUniversity of Florida, Gainesville, Florida, USA.
Joseph BonventreDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Alessandra BrendolanInternational Renal Research Institute of Vicenza, Vicenza, Italy.
Rolando Claure-Del GranadoDivision of Nephrology, Department of Medicine, Hospital Obrero No 2 Caja Nacional de Salud, Cochabamba, Bolivia.
David CollisterDivision of Nephrology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Lisa M CurtisDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kristin DolanDepartment of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.
Dana Y FuhrmanUPMC Department of Pediatrics, Pittsburgh, Pennsylvania, USA.
Zahraa HabeebDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Michael P HutchensDepartment of Anesthesiology, Oregon Health & Science University, Portland, Oregon, USA.
Kianoush B KashaniDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Nuttha LumlertgulExcellence Centre for Critical Care Nephrology, Division of Nephrology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Mignon McCullochDepartment of Paediatric Nephrology, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Shina MenonDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, California, USA.
Amira MohamedDivision of Critical Care Medicine, Montefiore Medical Center, Bronx, New York, USA.
Neesh PannuDivision of Nephrology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Karen ReueDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Claudio RoncoInternational Renal Research Institute of Vicenza, Vicenza, Italy.
Manisha SahayOsmania Medical College and Hospital, Kaloji University of Health Sciences, Hyderabad, Telangana, India.
Emily SeeDepartment of Intensive Care, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Michael ZappitelliHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Ravindra MehtaDepartment of Medicine, University of California San Diego Medical Center, San Diego, California, USA.
Marlies OstermannDepartment of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK.

Funding

Mechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2M
NIDDK NIH HHS R01 DK039773
6 · The paper itself

Abstract

Sex differences exist in acute kidney injury (AKI), and the role that sex and gender play along the AKI care continuum remains unclear. The 33rd Acute Disease Quality Initiative meeting evaluated available data on the role of sex and gender in AKI and identified knowledge gaps. Data from experimental models, pathophysiology, epidemiology, clinical care, gender, social determinants of health, education, and advocacy were reviewed. Recommendations include incorporating sex and gender into research along the bench-to-bedside spectrum; analyzing sex-stratified results; evaluating the effects of sex chromosomes, hormones, and gender on outcomes; considering fluctuations of hormone levels; studying the impact gender may have on access to care; and developing educational tools to inform patients, providers, and stakeholders. This meeting report summarizes what is known about sex and gender along the AKI care continuum and proposes an agenda for translational discovery to elucidate the role of sex and gender in AKI across the lifespan.

Indexed as

Acute Kidney InjuryFemaleHumansMaleRisk FactorsSex Factorsacute kidney injurygendersex differencessocial determinants of health

Identifiers

PMID39848406
PMCPMC13334715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.