Evidence map›Paper›PMID 39849149›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Early-phase

Cecilia Boccalini, Debora Elisa Peretti, Gregory Mathoux, Leonardo Iaccarino, Federica Ribaldi, Max Scheffler, Daniela Perani, Giovanni B Frisoni, Valentina Garibotto

Abstract readComparative Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The clinical Alzheimer's disease spectrum classified in the A/T/N framework withEuropean journal of nuclear medicine and molecular imaging · 2026
    Observational
  2. Detection of Focal Lesions in Epilepsy with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. SequentialFrontiers in neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cecilia BoccaliniLaboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-3518-436X
Debora Elisa PerettiLaboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-3033-8817
Gregory MathouxDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
Leonardo IaccarinoEli Lilly and Company, Indianapolis, USA.
Federica RibaldiMemory Clinic, Geneva University Hospitals, Geneva, Switzerland.
Max SchefflerDivision of Radiology, Geneva University Hospitals, Geneva, Switzerland.
Daniela PeraniNuclear Medicine Unit, San Raffaele Hospital, Milan, Italy.
Giovanni B FrisoniMemory Clinic, Geneva University Hospitals, Geneva, Switzerland.
Valentina GaribottoLaboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland. valentina.garibotto@hcuge.ch.ORCID 0000-0003-2422-698X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs dual-phase amyloid-PET can evaluate amyloid (A) and neurodegeneration (N) with a single tracer injection, dual-phase tau-PET might be able to provide both tau (T) and N. Our study aims to assess the association of early-phase tau-PET scans and

methods58 subjects evaluated at the Geneva Memory Center underwent dual-phase

resultsStrong positive correlations were found between eTAU and FDG SUVRs (r = 0.84, p < 0.001) and eTAU and eAMY SUVRs (r > 0.87, p < 0.001). Clusters of significant hypoperfusion with good correspondence to hypometabolism topographies were found at the individual level, independently of the underlying neurodegenerative patterns. Both eTAU and FDG SUVRs significantly distinguished A+/T + from A-/T- individuals (AUC

conclusionEarly-phase

Indexed as

Alzheimer DiseaseAmyloidBrainCarbolinesFluorodeoxyglucose F18Positron-Emission Tomographytau ProteinsAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiopharmaceuticals7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAmyloidCarbolinesFluorodeoxyglucose F18Radiopharmaceuticalstau Proteins18F-FDG PET18F-flortaucipirEarly-phase tau-PETNeurodegenerationPerfusion

Identifiers

PMID39849149
PMCPMC12014785

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.