ArticleBMC cardiovascular disorders2025
Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A novel nutritional index for hypertension risk and prediction: Cross-sectional, prospective, and trajectory evidence from the English Longitudinal Study of Ageing.The Journal of international medical research · 2026Article
- Observational
- Association of triglyceride-cholesterol-body weight index with in-hospital mortality in critically ill patients with heart failure.Scientific reports · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the triglyceride-total cholesterol-body weight index with new-onset cardiometabolic multimorbidity in middle-aged and older Chinese adults: evidence from a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between a novel nutritional index and coronary heart disease in COPD patients: a retrospective study in China.BMC pulmonary medicine · 2026Article
- Lipid-based atherogenic indices and their relationship with cardiovascular disease risk in an African population of type 2 diabetes mellitus patients.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Cross-Cultural Adaptation and Validation of the Simplified Diabetes Knowledge Test (Arabic Version) for Insulin-Dependent Diabetic Patients: A Cross-Sectional Study in Iraq.Journal of clinical medicine · 2026Article
- Comparison of novel nutritional index (TCBI) and insulin resistance index (TyG-BMI) for assessing cardiovascular disease risk: a cohort study.Journal of health, population, and nutrition · 2026Article
- A novel nutritional index and risk of edentulism: evidence from cross-sectional, prospective, and trajectory analyses.Lipids in health and disease · 2026Article
- A novel nutritional index for predicting stroke-heart syndrome and clinical outcomes after endovascular treatment.Frontiers in nutrition · 2026Article
- Association between the composite nutritional index TCBI and ISR.Frontiers in nutrition · 2026Article
- Emerging importance of remnant cholesterol compared with low-density lipoprotein cholesterol in cardiovascular risk assessment.Scientific reports · 2025Article
- Association of atherogenic indices and triglyceride-total cholesterol-body weight index (TCBI) with severity of stenosis in patients undergoing angiography: a case-control study.BMC research notes · 2025Article
- Unraveling the role of cumulative triglyceride-total cholesterol-body weight index in stroke development: evidence from the CHARLS cohort.Frontiers in medicine · 2025Article
- Association of a novel nutritional marker, the triglyceride-cholesterol-body weight index, with 90-day unfavorable outcomes in acute ischemic stroke: a prospective cohort study.Frontiers in nutrition · 2025Article
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13 authors.
Funding
Abstract
backgroundCardiovascular disease (CVD), a non-communicable condition, stands as the primary cause of death globally. This study seeks to evaluate the predictive power of atherogenic indices, which are recognized for their influence on CVD, alongside a newly developed index encompassing all three principal risk factors for CVD, referred to as the triglyceride-total cholesterol-body weight index (TCBI). The primary outcomes evaluated include both the incidence and mortality rates associated with CVD.
methodsA prospective cohort study was conducted on Mashhad stroke and heart atherosclerotic disorder (MASHAD) study data, involving 9704 healthy participants. Baseline variables were measured, and TCBI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli risk index I and II (CRI-I & II) were calculated using specific formulas.
resultsFollowing a 10-year follow-up period, a significant positive relationship was observed between TCBI (HR: 1.078, 95% CI: 1.012-1.15), CRI-I (HR: 1.16, 95% CI: 1.007-1.337), and CRI-II (HR: 1.199, 95% CI: 1.001-1.437) with CVD mortality. However, no significant relationship was identified between TCBI and atherogenic indices related to CVD incidence, and neither AIP nor AC was associated with CVD mortality.
conclusionIn conclusion, TCBI, in contrast to AC and AIP, was linked to increased CVD mortality. However, the more substantial predictive capabilities of CRI-I and CRI-II compared to TCBI emphasize the importance of traditional atherogenic indices for accurate risk assessment. These findings underscore the necessity of enhancing the TCBI formula to improve its effectiveness in assessing CVD risk.
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