ArticleFrontiers in public health2024
Preliminary study on the correlation between thyroid magnetic resonance parameters and radiation dose after radiotherapy for nasopharyngeal carcinoma.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypothyroidism is a common sequela after radiotherapy for nasopharyngeal carcinoma (NPC). Magnetic resonance imaging (MRI) has gained prominence in thyroid imaging, leveraging its non-ionizing radiation, high spatial resolution, multiparameter and multidirectional imaging. Few previous studies have investigated the evaluation of radiation-induced thyroid injury by MRI. Methods: MRI and radiotherapy data of 32 patients who were first diagnosed with nasopharyngeal carcinoma in our hospital from April 2015 to April 2024 and underwent radiotherapy in the radiotherapy department were retrospectively collected. Before, during and after radiotherapy, the thyroid morphology was observed on MR images, and the quantitative parameters of size (width, thickness) were measured on T1-weighted images. The signal intensity (SI) of the thyroid gland was measured on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging. The differences in thyroid parameters at different time points before and after radiotherapy were compared. The correlation between the MRI quantitative parameters of the thyroid and the radiation dose volume of the thyroid and the radiation dose of the pituitary were analyzed. Results: The width, thickness and volume of the thyroid decreased gradually before, during and 6 and 12 months after radiotherapy. They were negatively correlated with the mean thyroid dose and V50 ( Conclusion: Quantitative MRI analysis can non-invasively and effectively show the changes in thyroid shape, size and signal intensity in patients with nasopharyngeal carcinoma before and after radiotherapy, which is crucial for early and accurate assessment of thyroid damage, enabling timely treatment to preserve thyroid function.
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