Effective Synthesis of Dopamine Dimer.

Zhou Dejun, Zhang Yuying, Liu Xiaoyue, Zheng Huachuan

Abstract read

In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhou DejunInstitute of Chinese Medicine, Chengde Medical University, Chengde, 067000, China.ORCID 0000-0001-6432-1493

Zhang YuyingInstitute of Chinese Medicine, Chengde Medical University, Chengde, 067000, China.

Liu XiaoyueInstitute of Chinese Medicine, Chengde Medical University, Chengde, 067000, China.

Zheng HuachuanCancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.

Funding

Doctoral Initiation Fund of Chengde Medical College 202301Hebei Natural Science Foundation H2023406003, H2022406087, H2023406037Innovation and Entrepreneurship Education Teaching Reform Research and Practice Project of Department of Education of Hebei Province 2023cxcy147Postdoctoral Fund of Shandong Daguan Pharmaceutical Technology Co., LTD SDDG20230101-1

6 · The paper itself

Abstract

backgroundDopamine (1) is a commonly used vasopressor, primarily employed to treat various types of shock, congestive heart failure, and acute renal failure. Dopamine dimer (2) is an impurity generated during the production process of dopamine raw materials or the metabolism of dopamine drugs themselves.

methodsThis article presents an effective method for synthesizing dopamine dimer through the condensation of methyl 3,4-dimethoxyphenyl acetate (4) and 3,4-dimethoxyphenylethyl amine (5), followed by reduction and demethylation.

resultsThe product was synthesized from easily accessible raw materials, achieving a total yield of 48% over five steps.

conclusionThis synthesis method is simple and beneficial for pharmaceutical companies to adopt and implement.

Indexed as

DopamineDimerizationMolecular StructureDopamineclinical safetydimerDopamineimpuritysynthesisvasopressor

Identifiers

PMID39851117

DOI10.1016/j.neuron.2023.10.002

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.