ReviewCurrent neuropharmacology2025
Cortisol Imbalance and Fear Learning in PTSD: Therapeutic Approaches to Control Abnormal Fear Responses.
Review in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities.Cognitive processing · 2026Article
- Pre-trauma hair cortisol moderates adverse childhood experience and hypothalamic volume effects on stress symptoms after adult trauma.Translational psychiatry · 2026Article
- Screen, Sample, Stratify: Biomarkers and Machine Learning Compress Dementia Pathways.Biomedicines · 2026Article
- Successful Treatment of Recurrent Painful Muscle Spasms After Total Hip Arthroplasty With Oxcarbazepine: A Case Report.Clinical case reports · 2026Article
- The cortisol axis and psychiatric disorders: an updated review.Pharmacological reports : PR · 2025Review
- Deteriorated Gray Matter Connectome in Diabetic Kidney Disease: A Graph Theory Analysis of Individual-Level Gray Matter Morphological Networks.Brain and behavior · 2025Article
- Enhancing Human Action Inhibition Through Cortico-Cortical Paired Associative Stimulation.Annals of the New York Academy of Sciences · 2025Article
- Investigating Brain Functional Connectivity and Its Correlation With Cognitive Dysfunction in Chronic Kidney Disease Patients via Resting-State fMRI.Brain and behavior · 2025Article
- Symptom network connectivity in PTSD comorbid with depression in bereaved Chinese parents who have lost their only child.BMC psychiatry · 2025Article
- From Biomarkers to Behavior: Mapping the Neuroimmune Web of Pain, Mood, and Memory.Biomedicines · 2025Article
- From Microbial Switches to Metabolic Sensors: Rewiring the Gut-Brain Kynurenine Circuit.Biomedicines · 2025Review
- The Involvement of the Endocannabinoid, Glutamatergic, and GABAergic Systems in PTSD.International journal of molecular sciences · 2025Review
- Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study.Cellular and molecular neurobiology · 2025Article
- Dualistic Dynamics in Neuropsychiatry: From Monoaminergic Modulators to Multiscale Biomarker Maps.Biomedicines · 2025Article
- Aquaporins in Acute Brain Injury: Insights from Clinical and Experimental Studies.Biomedicines · 2025Review
- Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress.Biomedicines · 2025Article
- Editorial: Noninvasive brain stimulation: a promising approach to study and improve emotion regulation.Frontiers in behavioral neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Post-Traumatic Stress Disorder (PTSD) is mainly characterized by dysregulated fear responses, including hyperarousal and intrusive re-experiencing of traumatic memories. This work delves into the intricate interplay between abnormal fear responses, cortisol dysregulation, and the Hypothalamic-Pituitary-Adrenal (HPA) axis, elucidating their role in the manifestation of PTSD. Given the persistent nature of PTSD symptoms and the limitations of conventional therapies, innovative interventions are urgently needed. One promising avenue of research revolves around the modulation of cortisol through targeting receptors, with dexamethasone emerging as a critical agent capable of reducing cortisol levels, thus potentially aiding in the extinction of fear. In this study, we emphasize the need for innovative interventions in the neuropharmacological treatment of PTSD, focusing on cortisol modulation and its impact on fear regulation mechanisms. The complex interplay between the HPA axis, cortisol modulation, and fear dysregulation not only broadens our comprehension but also reveals promising paths to enhance therapeutic outcomes for individuals struggling with PTSD, underscoring a crucial need for more effective treatment strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.