Enhanced Detection Performance of Acute Vertebral Compression Fractures Using a Hybrid Deep Learning and Traditional Quantitative Measurement Approach: Beyond the Limitations of Genant Classification.

objectiveThis study evaluated the applicability of the classical method, height loss ratio (HLR), for identifying major acute compression fractures in clinical practice and compared its performance with deep learning (DL)-based VCF detection methods. Additionally, it examined whether combining the HLR with DL approaches could enhance performance, exploring the potential integration of classical and DL methodologies.

methodsEnd-to-End VCF Detection (EEVD), Two-Stage VCF Detection with Segmentation and Detection (TSVD_SD), and Two-Stage VCF Detection with Detection and Classification (TSVD_DC). The models were evaluated on a dataset of 589 patients, focusing on sensitivity, specificity, accuracy, and precision.

resultsTSVD_SD outperformed all other methods, achieving the highest sensitivity (84.46%) and accuracy (95.05%), making it particularly effective for identifying true positives. The complementary use of DL methods with HLR further improved detection performance. For instance, combining HLR-negative cases with TSVD_SD increased sensitivity to 87.84%, reducing missed fractures, while combining HLR-positive cases with EEVD achieved the highest specificity (99.77%), minimizing false positives.

conclusionThese findings demonstrated that DL-based approaches, particularly TSVD_SD, provided robust alternatives or complements to traditional methods, significantly enhancing diagnostic accuracy for acute VCFs in clinical practice.