ArticleBrain sciences2024
Short-Term Restriction of Physical and Social Activities Effects on Brain Structure and Connectivity.
Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.Translational psychiatry · 2025Pooled it
- Headache psychiatry: A structured narrative review and integrative framework.PCN reports : psychiatry and clinical neurosciences · 2026Review
- Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation.Psychopharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundProlonged confinement in enclosed environments has raised concerns about its effects on both physical and mental health. Although increased rates of depression or anxiety during COVID-19 lockdowns have been reported, the effects of short-term restrictions on social activities and physical on brain function and structure remain poorly known.
methodsThis study explored longitudinal changes in brain gray matter volume (GMV) and functional connectivity (FC) immediately after and four months following a short-term lockdown in comparison to pre-lockdown conditions. MRI data were collected from 20 participants before the lockdown, from 29 participants (14 original, 15 new) two months post-lockdown, and from 27 out of the 29 participants four months post-lifting of the lockdown.
resultsResults showed significant GMV reductions in the right gyrus rectus and cuneus post-lockdown, with further reductions observed four months after lifting the restrictions, affecting additional brain regions. Longitudinal FC trajectories revealed decreased connectivity between the default mode network (DMN) and sensorimotor/attention networks post-lockdown, and recovery after four months post-lifting of the lockdown.
conclusionsThe observed plasticity in brain FC indicates substantial recovery potential with the potential long-term effect of structural changes. Our findings offer insights into the effects of isolation on the human brain, potentially informing rehabilitation mechanisms and interventions for individuals in similar conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.