Evidence map›Paper›PMID 39851490›Full record

ArticleCells2025

The

Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-Ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tohru MatsukiDepartment of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.ORCID 0000-0003-1832-2406
Hidenori TabataDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.ORCID 0000-0003-3324-5998
Masashi UedaDepartment of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.
Hideaki ItoDepartment of Pathology, Aichi Medical University School of Medicine, Nagakute 480-1195, Aichi, Japan.
Koh-Ichi NagataDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.ORCID 0000-0002-6827-8434
Yumi TsuneuraDepartment of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.ORCID 0000-0002-2373-2752
Shima EdaDepartment of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.
Kenji KasaiDepartment of Pathology, Aichi Medical University School of Medicine, Nagakute 480-1195, Aichi, Japan.ORCID 0000-0001-6566-9483
Atsuo NakayamaDepartment of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan.ORCID 0000-0003-1444-0800

Funding

Japan Society for the Promotion of Science (JSPS) KAKENHI grant 20K08224 to AN.
6 · The paper itself

Abstract

Dendritic spine formation/maintenance is highly dependent on actin cytoskeletal dynamics, which is regulated by small GTPases Rac1 and Cdc42 through their downstream p21-activated kinase/LIM-kinase-I/cofilin pathway. ARHGEF7, also known as ß-PIX, is a guanine nucleotide exchange factor for Rac1 and Cdc42, thereby activating Rac1/Cdc42 and the downstream pathway, leading to the upregulation of spine formation/maintenance. We found that STIL, one of the primary microcephaly gene products, is associated with ARHGEF7 in dendritic spines and that knockdown of

Indexed as

Dendritic SpinesRho Guanine Nucleotide Exchange FactorsAnimalscdc42 GTP-Binding ProteinGuanine Nucleotide Exchange FactorsHumansMiceNeuronsrac1 GTP-Binding Proteincdc42 GTP-Binding ProteinGuanine Nucleotide Exchange Factorsrac1 GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsARHGEF7Cdc42dendritic spineMCPH7Rac1STIL

Identifiers

PMID39851490
PMCPMC11764357

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.