Evidence map›Paper›PMID 39851498›Full record

ReviewCells2025

Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures.

Enrique Estudillo, Jorge Iván Castillo-Arellano, Emilio Martínez, Edgar Rangel-López, Adolfo López-Ornelas, Roxana Magaña-Maldonado, Laura Adalid-Peralta, Iván Velasco, Itzel Escobedo-Ávila

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Enrique EstudilloLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0001-7918-2617
Jorge Iván Castillo-ArellanoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0002-3278-2348
Emilio MartínezLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0009-0007-7283-8274
Edgar Rangel-LópezLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0002-4741-1793
Adolfo López-OrnelasDivisión de Investigación, Hospital Juárez de México, Mexico City 07760, Mexico.
Roxana Magaña-MaldonadoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0003-4667-1208
Laura Adalid-PeraltaLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
Iván VelascoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0002-8953-6578
Itzel Escobedo-ÁvilaInstituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0003-1088-4658

Funding

CONAHCYT CF-2023-I-1552Hospital Juárez de México HJM 020/23-1Hospital Juárez de México HJM 023/22-1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez 72/20
6 · The paper itself

Abstract

Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing this task is challenging and complex since pregnant women display multiple confounding factors that make it difficult to identify the real effect of cannabinoids' consumption. Recent studies shed light on this issue by using pluripotent stem cells of human origin, which can recapitulate human neurodevelopment. These revolutionary platforms allow studying how exogenous cannabinoids could alter human neurodevelopment without ethical concerns and confounding factors. Here, we review the information to date on the clinical studies about the impact of exogenous cannabinoid consumption on human brain development and how exogenous cannabinoids alter nervous system development in humans using cultured pluripotent stem cells as 2D and 3D platforms to recapitulate brain development.

Indexed as

BrainCannabinoidsModels, BiologicalNeurogenesisFemaleHumansPluripotent Stem CellsPregnancyCannabinoidscell reprogrammingdrugsembryonic developmentneurogenesispregnancystem cells

Identifiers

PMID39851498
PMCPMC11763397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.