Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Natália Hogetop FreireChildren's Cancer Institute (ICI), Porto Alegre 90620-110, RS, Brazil.
Alice Laschuk HerlingerCancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.
Julia VaniniCancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.ORCID 0000-0002-9382-5460
Matheus DalmolinNational Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil.
Marcelo A C FernandesNational Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil.ORCID 0000-0001-7536-2506
Carolina NörThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Vijay RamaswamyThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-6557-895X
Caroline Brunetto de FariasChildren's Cancer Institute (ICI), Porto Alegre 90620-110, RS, Brazil.
André Tesainer BrunettoChildren's Cancer Institute (ICI), Porto Alegre 90620-110, RS, Brazil.ORCID 0000-0002-7958-1279
Algemir Lunardi BrunettoChildren's Cancer Institute (ICI), Porto Alegre 90620-110, RS, Brazil.ORCID 0000-0003-0668-6894
Lauro José GregianinCancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.
Mariane da Cunha JaegerChildren's Cancer Institute (ICI), Porto Alegre 90620-110, RS, Brazil.
Michael D TaylorThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Rafael RoeslerCancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.ORCID 0000-0001-6016-2261
Funding
Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4M
CCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastomaR01CA255369 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARZIA, LIVIA, TAYLOR, MICHAEL D. · 2021 to 2025
$3.9M
Prevention and treatment of lethal metastases in group 3 medulloblastomaR01NS106155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2018 to 2022
$2.8M
Brain Canada N/Ab.r.a.i.n.child N/ABrain Tumour Charity N/ABrain Tumour Foundation of Canada N/ACanada Research Chair in Pediatric Neuro-Oncology N/ACanadian Cancer Society Research Institute Impact grantCanadian Cancer Society Research Institute N/ACanadian Institutes for Health Research N/ACancer Prevention and Research Institute of Texas (CPRIT) CPRIT - RR220051Cancer Research UK Brain Tumour AwardChildren's Cancer Institute (ICI) N/AClinical Hospital (HCPA) institutional research fund 2020-0069Clinical Hospital (HCPA) institutional research fund 2023-0021C.R. Younger Foundation N/ACure Search Foundation N/AGarron Family Cancer Centre N/AGarron Family Chair in Childhood Cancer Research at the Hospital for Sick Children and the University of Toronto N/AGenome BC N/AGenome Canada N/AGenome Quebec N/AMatthew Larson Foundation (IronMatt) N/AMeagan's Walk N/AMinistry of Health/CNPq/FAPERGS PPSUS 21/2551-0000114-3National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) 101566/2022-0National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) 305647/2019-9National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) 405608/2021-7National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) 406484/2022-8National Institutes of Health (NIH) R01CA159859National Institutes of Health (NIH) R01CA255369National Institutes of Health (NIH) R01NS106155NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA255369NINDS NIH HHS R01 NS106155Ontario Institute for Cancer Research N/AOntario Research Fund N/APediatric Brain Tumor Foundation N/ARally Foundation for Childhood Cancer N/AStand Up To Cancer (SU2C) Cancer Stem Cell Dream Team Research Funding (SU2C-AACR-DT-19-15)Stand Up To Cancer (SU2C) St. Baldrick's Pediatric Dream Team Translational Research grant (SU2C-AACR-DT1113)Swifty Foundation N/ATerry Fox Research Institute N/ATexas Children's Cancer and Hematology Center Cyvia and Melvyn Wolff Chair of Pediatric Neuro-OncologyV Foundation for Cancer Research N/AWilliam Donald Nash Brain Tumour Research Fellowship N/AWorldwide Cancer Research N/A
6 · The paper itself
Abstract
Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy. Here, we show that VPA reduced medulloblastoma (MB) cell viability and led to cell cycle arrest. These effects were accompanied by enhanced H3K9 histone acetylation (H3K9ac) and decreased expression of the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres. · full record | Socratic