Evidence map›Paper›PMID 39852121›Full record

ReviewCurrent issues in molecular biology2024

Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions.

Hyeon-Jeong Hwang, Youngsang Nam, Chanhee Jang, Eun La Kim, Eun Seo Jang, Yeo Jin Lee, Seoung Rak Lee

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyeon-Jeong HwangCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Youngsang NamCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Chanhee JangCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Eun La KimCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Eun Seo JangCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Yeo Jin LeeCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Seoung Rak LeeCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.

Funding

Pusan National University 2-Year Research Grant of Pusan National University
6 · The paper itself

Abstract

Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as a promising source of anticancer compounds, offering unique structural diversity and potent biological activity. This review identifies and discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures and reported cytotoxic activities against cancer cell lines. Notably, plant-derived RiPPs such as rubipodanin A and mallotumides A-C demonstrated low nanomolar IC

Indexed as

anticancer activitybiosynthesischemical structurephytochemicalsribosomally synthesized and post-translationally modified peptides

Identifiers

PMID39852121
PMCPMC11764418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.