Evidence map›Paper›PMID 39852157›Full record

ArticleCurrent issues in molecular biology2025

Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers.

Maksym Zoziuk, Vittorio Colizzi, Pavlo Krysenko, Maurizio Mattei, Roberta Bernardini, Fabio Massimo Zanzotto, Stefano Marini, Dmitri Koroliouk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Human miRNAs in Cancer: Statistical Trends and Cross Kingdom Approach.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maksym ZoziukCentro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Vittorio ColizziUNESCO Chair in Interdisciplinary Biotechnology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00173 Rome, Italy.
Pavlo KrysenkoInstitute of Telecommunications and Global Information Space of the National Academy of Sciences of Ukraine, Chokolivskiy bulv. 13, 03186 Kyiv, Ukraine.
Maurizio MatteiCentro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-0814-8873
Roberta BernardiniFaculty of Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Roma, Italy.ORCID 0000-0002-1675-0645
Fabio Massimo ZanzottoDepartment of Business Engineering "Mario Lucertini", University of Rome Tor Vergata, Via del Politecnico, 1, 00133 Rome, Italy.ORCID 0000-0002-7301-3596
Stefano MariniFaculty of Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Roma, Italy.
Dmitri KorolioukCentro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-2765-3450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level. The identified deficient miRNAs are compared with their target genes for coincidences in their expression directions. The replacement of human miRNAs is proposed to be implemented, using plant miRNAs closest to the human-deficient ones. Such plant substitutes are identified by analyzing the average complementarity of all human under-expressed miRNAs. It was established that the number of downregulated miRNAs is almost 2.5 times greater than that of upregulated miRNAs. There is no significant correlation between the expression of miRNA and genes, implying many other expression regulation mechanisms exist. Working on the organization of experimental verification of the obtained statistical studies, we present significant regularities that provide grounds for considering some plant microRNAs as possible means of compensating for insufficient expression of regulatory microRNAs in humans and animals in a wide range of oncological diseases.

Indexed as

cancer treatmentmiRNA expressionplant miRNAsstatistical complementarity

Identifiers

PMID39852157
PMCPMC11763636

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.