Evidence mapPaperPMID 39852564Full record

ReviewJournal of functional biomaterials2025

Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes.

Virendra Kumar Yadav, Rachna Gupta, Abdullah A Assiri, Jalal Uddin, Azfar A Ishaqui, Pankaj Kumar, Khalid M Orayj, Shazia Tahira, Ashish Patel, Nisha Choudhary

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Liposomal formulation ofRSC advances · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Virendra Kumar YadavMarwadi University Research Center, Department of Microbiology, Faculty of Sciences, Marwadi University, Rajkot 360003, Gujarat, India.ORCID 0000-0001-5448-7676
Rachna GuptaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382021, Gujarat, India.
Abdullah A AssiriDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0002-8721-1331
Jalal UddinDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0002-8613-4493
Azfar A IshaquiDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0003-0688-2625
Pankaj KumarDepartment of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara 391760, Gujarat, India.ORCID 0000-0001-5069-0888
Khalid M OrayjDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0001-6651-2306
Shazia TahiraInstitute of Professional Psychology, Bahria University Karachi Campus, Karachi 75260, Pakistan.ORCID 0000-0001-6327-2044
Ashish PatelDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan 384265, Gujarat, India.ORCID 0000-0003-4612-1724
Nisha ChoudharyDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan 384265, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Each year, the number of cases of strokes and deaths due to this is increasing around the world. This could be due to work stress, lifestyles, unhealthy food habits, and several other reasons. Currently, there are several traditional methods like thrombolysis and mechanical thrombectomy for managing strokes. The current approach has several limitations, like delayed diagnosis, limited therapeutic delivery, and risks of secondary injuries. So, there is a need for some effective and reliable methods for the management of strokes, which could help in early diagnosis followed by the treatment of strokes. Nanotechnology has played an immense role in managing strokes, and recently, it has emerged as a transformative solution offering innovative diagnostic tools and therapeutic strategies. Nanoparticles (NPs) belonging to several classes, including metallic (metallic and metal oxide), organic (lipids, liposome), and carbon, can cross the blood-brain barrier and may exhibit immense potential for managing various strokes. Moreover, these NPs have exhibited promise in improving imaging specificity and therapeutic delivery by precise drug delivery and real-time monitoring of treatment efficacy. Nanomaterials like cerium oxide (CeO

Indexed as

blood–brain barrierdrug deliverynanomaterialsnanomedicinestroke

Identifiers

PMID39852564
PMCPMC11766075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.