ArticleJournal of functional biomaterials2025
An Evaluation of the Biocompatibility and Chemical Properties of Two Bioceramic Root Canal Sealers in a Sealer Extrusion Model of Rat Molars.
Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Effect of the Gutta Condensor on Powder-Liquid and Ready-to-Use Hydraulic Sealers.Journal of clinical and experimental dentistry · 2026Review
- Calcium Silicate-Based Cements for Vital Pulp Therapy: Integrated Assessment of Radiopacity, Elemental Composition, and 24-h Pulp Cell Responses.Biomimetics (Basel, Switzerland) · 2026Article
- Localization of Gli1-expressing cells after pulp revascularization and their involvement in newly formed mineralized tissue in mice.Scientific reports · 2026Article
- Bioactive Materials and Novel Techniques in Endodontics: Translational Advances for Clinical Practice.Journal of functional biomaterials · 2026Article
- Ex vivo comparative analysis of retrievability among four calcium silicate-based sealers for regaining apical patency.Restorative dentistry & endodontics · 2026Article
- Non-Surgical Management of Apical Fenestration Associated with Apical Periodontitis in a Tooth with an Open Apex: A Case Report.Reports (MDPI) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
This study assessed the biocompatibility and chemical properties of two bioceramic root canal sealers, EndoSequence BC Sealer (EBC) and Nishika Canal Sealer BG (NBG), using a sealer extrusion model. Eight-week-old male Wistar rats were used. The mesial root canals of the upper first molars were pulpectomized and overfilled with EBC, NBG, or, as reference, epoxy resin-based AH Plus (AHP). After 28 days, periapical tissue reactions were assessed using microcomputed tomography and histological staining. The elemental composition and chemical composition of the extruded EBC and NBG were analyzed at Day 1 and 28 using an electron probe microanalyzer and micro-Raman spectroscopy. No periapical lesions were observed with the sealer extrusion. Additionally, inflammation around the extruded EBC and NBG was minimal to mild on Day 28, whereas moderate inflammation was found around the extruded AHP. Silicon concentration in the extruded EBC and NBG decreased significantly from Day 1 to 28, with almost no silicon present on Day 28. Furthermore, the extruded EBC and NBG became calcium- and phosphorus-rich, showing a Raman band for hydroxyapatite on Day 28. In conclusion, EBC and NBG demonstrated favorable biocompatibility and the ability to release silicon elements and produce hydroxyapatite when extruded into the periapical tissues. AHP showed moderate periapical tissue irritancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.