Evidence map›Paper›PMID 39852578›Full record

ArticleJournal of functional biomaterials2025

The Effect of Surface Functionalization of Magnesium Alloy on Degradability, Bioactivity, Cytotoxicity, and Antibiofilm Activity.

Morena Nocchetti, Michela Piccinini, Donatella Pietrella, Cinzia Antognelli, Maurizio Ricci, Alessandro Di Michele, Layla Jalaoui, Valeria Ambrogi

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Morena NocchettiDepartment of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-2927-1130
Michela PiccininiDepartment of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.
Donatella PietrellaDepartment of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0003-1572-4290
Cinzia AntognelliDepartment of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0002-8259-680X
Maurizio RicciDepartment of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-3373-9771
Alessandro Di MicheleDepartment of Physics and Geology, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-0357-2608
Layla JalaouiDepartment of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.
Valeria AmbrogiDepartment of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-4204-9243

Funding

European Union - NextGenerationEU ECS00000041
6 · The paper itself

Abstract

Magnesium alloys are promising biomaterials to be used as temporary implants due to their biocompatibility and biodegradability. The main limitation in the use of these alloys is their rapid biodegradation. Moreover, the risk of microbial infections, often following the implant surgery and hard to eradicate, is another challenge. Thus, with the aim of reducing biodegradability and conferring antibiofilm activity, sheets of the magnesium alloy AZ31 were properly modified with the introduction of hydroxy (polyethyleneoxy)propyl silane (PEG) and quaternary ammonium silane chains (QAS). The derivatized sheets were characterized by ATR-FTIR spectroscopy and their performances as concerns their stability, Mg

Indexed as

antibiofilm activitybone implantscytotoxicityin vitro bioactivitymagnesium alloystabilitysurface functionalization

Identifiers

PMID39852578
PMCPMC11765666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.