Evidence map›Paper›PMID 39853492›Full record

ArticleJournal of neurology2025

Characterizing the underlying microangiopathy of deep cerebellar intracerebral hemorrhage.

Alvin S Das, Avia Abramovitz Fouks, Elif Gökçal, Ofer Rotschild, Marco Pasi, Robert W Regenhardt, Joshua N Goldstein, Anand Viswanathan, Jonathan Rosand, Steven M Greenberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alvin S DasDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. adas4@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-2313-977X
Avia Abramovitz FouksDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Elif GökçalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ofer RotschildDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marco PasiCentre Hospitalier, Université de Tours, Tours, France.
Robert W RegenhardtDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joshua N GoldsteinDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anand ViswanathanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jonathan RosandDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
M Edip GurolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Vascular Dysfunction in Cerebral Amyloid AngiopathyR01AG026484 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2005 to 2019
$7.5M
CEREBRAL AMYLOID ANGIOPATHY AND MECHANISMS OF BRAIN AMYLOID ACCUMULATIONR01NS096730 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J, GREENBERG, STEVEN M · 2016 to 2020
$5.7M
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyR01NS114526 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2020 to 2024
$4.4M
Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Molecular Neuroimaging of Disease Mechanisms in Cerebral Amyloid AngiopathyK23NS083711 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2014 to 2018
$988k
Andrew David Heitman Foundation 1200-236980NIA NIH HHS R01 AG026484NINDS NIH HHS 5R01AG026484NINDS NIH HHS 5R01NS096730-04NINDS NIH HHS K23 NS083711NINDS NIH HHS NS083711NINDS NIH HHS R01 NS096730NINDS NIH HHS R01 NS103924NINDS NIH HHS R01NS103924NINDS NIH HHS R01 NS114526NINDS NIH HHS R01NS114526NINDS NIH HHS U01NS069673
6 · The paper itself

Abstract

introductionWhile cerebral amyloid angiopathy is likely responsible for intracerebral hemorrhage (ICH) occurring in superficial (grey matter, vermis) cerebellar locations, it is unclear whether hypertensive arteriopathy (HA), the other major cerebral small vessel disease (cSVD), is associated with cerebellar ICH (cICH) in deep (white matter, deep nuclei, cerebellar peduncle) regions. We tested the hypothesis that HA-associated neuroimaging markers are significantly associated with deep cICH compared to superficial cICH. PATIENTS AND

methodsBrain MRI scans from consecutive non-traumatic cICH patients admitted to a referral center were analyzed for cSVD markers. Clinical risk factors, left ventricular hypertrophy (LVH, a marker of hypertensive end-organ damage), and neuroimaging markers were compared between patients with deep and superficial cICH in univariate and multivariable models.

resultsHypertension and LVH were more common among 83 (64%) patients with deep cICH compared to 46 (36%) with superficial cICH. HA-related markers such as peri-basal ganglia white matter hyperintensity pattern, deep lacunes, severe basal ganglia enlarged perivascular spaces, and deep cerebral microbleeds (CMBs) were more common among those with deep vs. superficial cICH. Strictly lobar CMBs were less common among patients with deep cICH, whereas mixed-location CMBs were more common. After multivariable adjustment, LVH (aOR 4.06, 95% CI [1.22-13.50], p = 0.02), deep lacunes (aOR 6.02, 95% CI [1.46-24.89], p = 0.01), and strictly lobar CMBs (aOR 0.09, 95% CI [0.02-0.45], p < 0.01) remained significantly associated with deep cICH. DISCUSSION AND

conclusionBecause HA-associated markers are significantly associated with deep cICH, it is likely HA is the dominant underlying microangiopathy of this ICH subtype.

Indexed as

Cerebellar DiseasesCerebellumCerebral HemorrhageCerebral Small Vessel DiseasesAgedAged, 80 and overFemaleHumansHypertensionMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesRisk FactorsCerebral amyloid angiopathyCerebral small vessel diseaseHypertensionIntracerebral hemorrhageNeuroimaging

Identifiers

PMID39853492
PMCPMC13539573

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.