Evidence map›Paper›PMID 39853950›Full record

ReviewJournal of integrative plant biology2025

Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.

Yuhong Li, Tianjun Cao, Yunling Guo, Bernhard Grimm, Xiaobo Li, Deqiang Duanmu, Rongcheng Lin

Abstract readReview
In one paragraph

Review in Journal of integrative plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuhong LiKey Laboratory of Photobiology, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China.ORCID http://orcid.org/0000-0002-4299-7772
Tianjun CaoSchool of Life Sciences, Westlake University, Hangzhou, 310030, China.ORCID http://orcid.org/0000-0003-3775-2081
Yunling GuoState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0003-0665-4702
Bernhard GrimmInstitute of Biology/Plant Physiology, Humboldt-Universität zu Berlin, Berlin, 10115, Germany.ORCID http://orcid.org/0000-0002-9730-1074
Xiaobo LiSchool of Life Sciences, Westlake University, Hangzhou, 310030, China.ORCID http://orcid.org/0000-0003-3951-9646
Deqiang DuanmuState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0002-9365-362X
Rongcheng LinKey Laboratory of Photobiology, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China.ORCID http://orcid.org/0000-0001-8346-3390

Funding

Key Research and Development Program of Zhejiang Province 2024SSYS0100National Key Research and Development Program of China 2019YFA0906300National Key Research and Development Program of China 2020YFA0907601National Key Research and Development Program of China and 2022YFC3401800
6 · The paper itself

Abstract

Plants, algae and photosynthetic bacteria convert light into chemical energy by means of photosynthesis, thus providing food and energy for most organisms on Earth. Photosynthetic pigments, including chlorophylls (Chls) and carotenoids, are essential components that absorb the light energy necessary to drive electron transport in photosynthesis. The biosynthesis of Chl shares several steps in common with the biosynthesis of other tetrapyrroles, including siroheme, heme and phycobilins. Given that many tetrapyrrole precursors possess photo-oxidative properties that are deleterious to macromolecules and can lead to cell death, tetrapyrrole biosynthesis (TBS) requires stringent regulation under various developmental and environmental conditions. Thanks to decades of research on model plants and algae, we now have a deeper understanding of the regulatory mechanisms that underlie Chl synthesis, including (i) the many factors that control the activity and stability of TBS enzymes, (ii) the transcriptional and post-translational regulation of the TBS pathway, and (iii) the complex roles of tetrapyrrole-mediated retrograde signaling from chloroplasts to the cytoplasm and the nucleus. Based on these new findings, Chls and their derivatives will find broad applications in synthetic biology and agriculture in the future.

Indexed as

Biosynthetic PathwaysChlorophyllPlantsSignal TransductionChloroplastsGene Expression Regulation, PlantPhotosynthesisTetrapyrrolesChlorophyllTetrapyrroleschlorophyll biosynthesisregulationsignaling

Identifiers

PMID39853950
PMCPMC12016751

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.