ArticleAmerican journal of physiology. Cell physiology2025
Sex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis.
Philomena Entsie, Emmanuel Boadi Amoafo, Ying Kang, Thomas Gustad, Glenn P Dorsam, Mark R Frey, Elisabetta Liverani
Abstract read
In one paragraphArticle in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Philomena EntsieDepartment of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, North Dakota, United States.ORCID 0000-0002-4858-8339 Emmanuel Boadi AmoafoDepartment of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, North Dakota, United States.
Ying KangDepartment of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, North Dakota, United States.
Thomas GustadDepartment of Microbiological Sciences, College of Agriculture, Food Systems and Natural Resources, North Dakota State University, Fargo, North Dakota, United States.
Glenn P DorsamDepartment of Microbiological Sciences, College of Agriculture, Food Systems and Natural Resources, North Dakota State University, Fargo, North Dakota, United States.
Mark R FreyDepartment of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-2561-5402 Elisabetta LiveraniDepartment of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, North Dakota, United States.ORCID 0000-0001-5540-0456 Funding
Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Sanku Mallik · 2016 to 2026
$20.5MSex-related variations in the response of drug therapies targeting purinergic signaling pathways in sepsisR21AI156627 · NIAID · NORTH DAKOTA STATE UNIVERSITY · PI LIVERANI, ELISABETTA · 2021 to 2022
$399kHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI156627-01NIAID NIH HHS R21 AI156627NIGMS NIH HHS P20 GM109024
6 · The paper itselfAbstract
Intra-abdominal sepsis is a life-threatening complex syndrome caused by microbes in the gut microbiota invading the peritoneal cavity. It is one of the major complications of intra-abdominal surgery. To date, only supportive therapies are available. No studies have investigated the progression of intra-abdominal sepsis in the peritoneal cavity. Our group has shown that platelets play an essential role during sepsis, and blocking purinergic signaling in platelets through P2Y
Indexed as
Blood PlateletsCytokinesPeritoneal CavityPhagocytosisSepsisAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Sex FactorsSignal TransductionCytokinesP2ry12 protein, mousePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Ticagrelorimmune cellsintra-abdominal sepsisplateletspurinergic signaling
Identifiers
PMID39854048
PMCPMC13089027
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