Evidence map›Paper›PMID 39854121›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025

Regulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women.

Kyle S Wiley, Laura E Martínez, Daylon Kwon, Delaney A Knorr, Marta Epeldegui, Molly M Fox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyle S WileyDepartment of Anthropology, University of California, Los Angeles, California, USA.ORCID 0000-0003-0233-9561
Laura E MartínezUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-9804-6001
Daylon KwonDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, California, USA.ORCID 0000-0001-7967-8508
Delaney A KnorrDepartment of Anthropology, University of California, Los Angeles, California, USA.ORCID 0000-0002-5105-8742
Marta EpeldeguiUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-7605-5994
Molly M FoxDepartment of Anthropology, University of California, Los Angeles, California, USA.ORCID 0000-0001-9219-8971

Funding

Effects of Acculturation on Gestational Biology in Mexican-American Pregnant WomenK01DK105110 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2015 to 2021
$782k
How women’s reproductive life-history relates to cognitive decline and neuropathology in Alzheimer’s disease and related dementiasR21AG079093 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2023 to 2024
$381k
Social adversity, gestational stress physiology, and birth outcomes in Hispanic AmericansR03DK125524 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2020 to 2021
$234k
Mental health across generations of Hispanic Americans: investigating the biomechanism of fetal programmingF32MD015201 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILEY, KYLE STEVEN · 2020 to 2022
$198k
NIA NIH HHS R21 AG079093NIA NIH HHS R21AG079093-01A1NIDDK NIH HHS K01 DK105110NIDDK NIH HHS R03 DK125524NIHNIMHD NIH HHS F32 MD015201UCLA Center for the Study of Women Faculty Research Grant
6 · The paper itself

Abstract

problemRegulatory B-cells (Bregs, CD19

methodPeripheral blood samples were obtained from 29 pregnant women at mean 12 weeks' gestation. Participants were age ≥ 18, self-identified as Latina/Hispanic, and N = 12 primigravid. Peripheral blood mononuclear cells were isolated, stained, and analyzed by flow cytometry to determine percentages of Tregs from CD4

resultsBregs positively correlated with pro-inflammatory cytokine interleukin (IL)-6. PD-L1

conclusionsThis study provides insight into the immunosuppressive role of Bregs and PD-L1

Indexed as

B-Lymphocytes, RegulatoryCytokinesT-Lymphocytes, RegulatoryAdultB7-H1 AntigenFemaleHumansPregnancyYoung AdultB7-H1 AntigenCD274 protein, humanCytokinesfetal toleranceIL‐10IL‐6immunoregulationPD‐L1pregnancyregulatory B‐cellsregulatory T‐cells

Identifiers

PMID39854121
PMCPMC12001748

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.