Evidence map›Paper›PMID 39855040›Full record

ArticleBiochemical and biophysical research communications2025

Expression of fatty acid binding proteins in mesenteric adipose tissue.

Shayla R Fish, Catherine L Halley, Mythili Dileepan, Ann V Hertzel, Deborah M Dickey, David A Bernlohr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shayla R FishDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Catherine L HalleyDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Mythili DileepanDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA; Institute on the Biology of Aging and Metabolism, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Ann V HertzelDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA; Institute on the Biology of Aging and Metabolism, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Deborah M DickeyDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
David A BernlohrDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA; Institute on the Biology of Aging and Metabolism, University of Minnesota-Twin Cities, Minneapolis, MN, USA. Electronic address: Bernl001@umn.edu.

Funding

LIPID BINDING PROTEINS IN OBESITY/DIABETES SYNDROMESR01DK053189 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1998 to 2020
$5.6M
Inflammation, Lipid Metabolism and SenescenceR01AG069819 · NIA · UNIVERSITY OF MINNESOTA · PI CAMELL, CHRISTINA · 2020 to 2024
$1.9M
NIA NIH HHS R01 AG069819NIDDK NIH HHS R01 DK053189
6 · The paper itself

Abstract

Adipose is a complex tissue comprised of adipocytes, immune cells, endothelial and progenitor stem cells. In humans, there are at least nine defined adipose depots, each containing variable numbers of genetically identified adipocyte clusters suggesting remarkable heterogeneity and potential functionality in each depot with respect to lipid metabolism. Although subcutaneous and visceral depots are commonly analyzed for biochemical and molecular functions, the mesenteric depot has been overlooked yet strongly implicated in lipid mediated immune surveillance. Since fatty acid binding proteins (FABPs) are primary cellular conduits to lipid trafficking, we evaluated the expression patterns for four major fatty acid binding proteins (FABP1, FABP3, FABP4 and FABP5) using a combination of gene expression, immunoblotting, and immunofluorescence in mesenteric fat from both young and old, male and female C57Bl/6J mice. All four FABPs were expressed at the mRNA and protein level in murine mesenteric adipose tissue. While there was no statistical change in expression of mesenteric FABP isoforms with sex or age, the expression of mesenteric FABP1 was increased, and FABP4 decreased, in both males and females as compared to perigonadal and inguinal depots. Surprisingly, immunofluorescence staining revealed that compared to subcutaneous or perigonadal depots, mesenteric fat expresses FABP3, but little FABP5, in adipocytes. These results highlight the diversity in adipose tissue and the importance of evaluating the mesenteric depot in the context of lipid transport and metabolism.

Indexed as

Adipose TissueFatty Acid-Binding ProteinsMesenteryAnimalsFatty Acid Binding Protein 3FemaleMaleMiceMice, Inbred C57BLNeoplasm ProteinsFabp1 protein, mouseFabp3 protein, mouseFabp4 protein, mouseFabp5 protein, mouseFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsNeoplasm ProteinsFatty acid binding proteinsLipid traffickingMesenteryVisceral adipose

Identifiers

PMID39855040
PMCPMC12312445

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.