Evidence map›Paper›PMID 39856074›Full record

ArticleScientific reports2025

An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish.

Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N Meyer, Richard Di Giulio, Caren Weinhouse

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Samantha CarrothersOregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA.
Rafael TrevisanNicholas School of the Environment, Duke University, 27701, Durham, NC, USA.
Nishad JayasundaraNicholas School of the Environment, Duke University, 27701, Durham, NC, USA.
Nicole PelletierOregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA.
Emma WeeksOregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA.
Joel N MeyerNicholas School of the Environment, Duke University, 27701, Durham, NC, USA.
Richard Di GiulioNicholas School of the Environment, Duke University, 27701, Durham, NC, USA.
Caren WeinhouseOregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA. weinhous@ohsu.edu.

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
NIEHS NIH HHS P42 ES010356NIEHS NIH HHS P42ES010356
6 · The paper itself

Abstract

Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant public health problem that will worsen with a warming climate and increased large-scale wildfires. Here, we characterize an epigenetic memory at the cytochrome P450 1 A (CYP1A) gene in wild Fundulus heteroclitus that have adapted to chronic, extreme PAH pollution. In wild-type fish, CYP1A is highly induced by PAH. In PAH-tolerant fish, CYP1A induction is blunted. Since CYP1A metabolically activates PAH, this memory protects these fish from PAH-mediated cancer. However, PAH-tolerant fish reared in clean water recover CYP1A inducibility, indicating a non-genetic effect. We observed epigenetic control of this reversible memory of generational PAH stress in F

Indexed as

Cytochrome P-450 CYP1A1Epigenesis, GeneticFundulidaeNeoplasmsPolycyclic Aromatic HydrocarbonsAnimalsEpigenetic MemoryPromoter Regions, GeneticWater Pollutants, ChemicalCytochrome P-450 CYP1A1Polycyclic Aromatic HydrocarbonsWater Pollutants, ChemicalEnvironmental plasticityEpigeneticsFundulus heteroclitusPolycyclic aromatic hydrocarbons

Identifiers

PMID39856074
PMCPMC11759692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.