ReviewTranslational psychiatry2025
The interface of depression and diabetes: treatment considerations.
Review in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis.Psychopharmacology · 2026Article
- Transdiagnostic Assessment of Mental Health and Sleep Registry: Protocol for a Cross-Sectional Study.Alpha psychiatry · 2026Article
- Article
- Systematic review and meta-analysis on depression burden among Type 2 diabetes patients in India.Diabetology & metabolic syndrome · 2026Review
- ATP and major affective disorders: the involvement of P2X receptors in pathophysiology.Purinergic signalling · 2026Review
- Association between glycemic control, mental problems and nutrition in individuals with type 1 and type 2 diabetes mellitus in primary care settings.BMC public health · 2026Article
- An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression.BMC psychiatry · 2026Article
- Depression Risk in Type 1 Versus Type 2 Diabetes: Cross-Sectional Analysis of Body Mass Index (BMI) in a Nationally Diverse Cohort.Endocrinology, diabetes & metabolism · 2026Article
- Association BetweenBrain sciences · 2026Article
- Association rule analysis of physical activity and multimorbidity in middle-aged Korean adults with diabetes: an evidence to promote active lifestyles.BMC public health · 2026Article
- Bidirectional Mendelian Randomisation Analysis of Gastric Cancer and Depression: Evidence for the Causal Effect of Cancer on Depression.Actas espanolas de psiquiatria · 2026Article
- Analysis of Anxiety and Depression Status and Risk Factors in Postmenopausal Women With Diabetes Mellitus Complicated by Hypothyroidism.Actas espanolas de psiquiatria · 2026Article
- The relationship between fasting blood glucose, glycated hemoglobin, fructosamine, and depression in patients with type 2 diabetes mellitus in South Korea: a secondary analysis of the Korea National Health and Nutrition Examination Survey VIII-2 (2020) data.Journal of Korean biological nursing science · 2026Article
- Social, psychosocial, and lifestyle determinants of diabetes and prediabetes in US adults before and after COVID-19: a cross-sectional NHANES analysis.Diabetology & metabolic syndrome · 2026Article
- Antidepressants and Risk of Mortality in People with Depressive Disorder and Co-Occurring Type 2 Diabetes Mellitus: A 20-Year Population-Based Cohort Study.Psychotherapy and psychosomatics · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Psychological Distress and Health-Related Quality of Life in Romanian Adults with Diabetes Mellitus: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Ketamine in Diabetes Care: Metabolic Insights and Clinical Applications.Pharmaceutics · 2026Review
- Integrated gut microbiota and metabolome analyses link anger to metabolic dysregulation in patients with type 2 diabetes mellitus.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions. Depression and diabetes often co-occur and share genetic, lifestyle, and psychosocial risk factors. Lifestyle elements such as diet, physical activity, and sleep patterns play a role on the development and management of both conditions, highlighting the need for integrated treatment strategies. The evidence suggests that traditional management strategies focusing on either condition in isolation fall short of addressing the intertwined nature of diabetes and depression. Instead, integrated care models encompassing psychological support and medical management are recommended to improve treatment efficacy and patient adherence. Such models require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, and primary care, to offer a holistic approach to patient care. This review also identifies significant patient-related barriers to effective management, such as stigma, psychological resistance, and health literacy, which need to be addressed through patient-centered education and support systems. Future directions for research include longitudinal studies in diverse populations to further elucidate causal relationships and the exploration of novel therapeutic targets, as well as the effectiveness of healthcare models aimed at preventing the onset of one condition in individuals diagnosed with the other.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.