Evidence map›Paper›PMID 39856330›Full record

ArticleOncogene2025

S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers.

Samson Mugisha, Shahnawaz A Baba, Shreyas Labhsetwar, Devam Dave, Aran Zakeri, Richard Klemke, Jay S Desgrosellier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Asparagine endopeptidase prompts breast cancer-related pericardial calcification by regulating IGF2 and integrin αvβ5.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samson MugishaDepartment of Pathology, University of California, San Diego, La Jolla, USA.ORCID http://orcid.org/0000-0003-1528-204X
Shahnawaz A BabaDepartment of Pathology, University of California, San Diego, La Jolla, USA.
Shreyas LabhsetwarDepartment of Pathology, University of California, San Diego, La Jolla, USA.
Devam DaveDepartment of Pathology, University of California, San Diego, La Jolla, USA.
Aran ZakeriDepartment of Pathology, University of California, San Diego, La Jolla, USA.
Richard KlemkeDepartment of Pathology, University of California, San Diego, La Jolla, USA.
Jay S DesgrosellierDepartment of Pathology, University of California, San Diego, La Jolla, USA. jdesgrosellier@ucsd.edu.ORCID http://orcid.org/0000-0001-8097-0143

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
California Breast Cancer Research Program (CBCRP) B28IB5479NCI NIH HHS P30 CA023100Tobacco-Related Disease Research Program (TRDRP) T32IR4741
6 · The paper itself

Abstract

Smoking plays an underappreciated role in breast cancer progression, increasing recurrence and mortality in patients. Here, we show that S100A8/A9 innate immune signaling is a molecular mechanism that identifies smoking-related breast cancers and underlies their enhanced malignancy. In contrast to acute exposure, chronic nicotine increased tumorigenicity and reprogrammed breast cancer cells to express innate immune response genes. This required the α7 nicotinic acetylcholine receptor, which elicited dynamic changes in cell differentiation, proliferation, and expression of secreted cytokines, such as S100A8 and S100A9, as assessed by unbiased scRNA-seq. Indeed, pharmacologic or genetic inhibition of S100A8/A9-RAGE receptor signaling blocked nicotine's tumor-promoting effects. We also discovered Syntaphilin (SNPH) as an S100A8/A9-dependent gene enriched specifically in estrogen receptor-negative (ER

Indexed as

Breast NeoplasmsCalgranulin ACalgranulin BImmunity, InnateSmokingalpha7 Nicotinic Acetylcholine ReceptorAnimalsCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMiceNicotineSignal Transductionalpha7 Nicotinic Acetylcholine ReceptorCalgranulin ACalgranulin BChrna7 protein, humanNicotineS100A8 protein, humanS100A9 protein, human

Identifiers

PMID39856330
PMCPMC11976259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.