ArticleEye (London, England)2025
Non-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Arterial-related craniospinal physiological compliance assessed by phase-contrast MRI and lumbar infusion test.Brain communications · 2026Article
- An eye on long-duration spaceflight: Controversies, countermeasures and challenges.Experimental physiology · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesIdiopathic intracranial hypertension (IIH) is a disease which threatens vision and causes disabling headaches, affecting women of childbearing age with obesity. It is characterised by raised intracranial pressure (ICP), measured invasively either with lumbar punctures or intracranially-inserted monitors. There is an unmet clinical need to develop non-invasive means to assess ICP. This study aims to utilise the MRI-ICP imaging technique to measure intracranial compliance index and assess its suitability as surrogate biomarker of ICP. SUBJECTS/
methodsNine IIH patients and ten age, sex, and body mass index matched healthy controls were recruited. All participants underwent lumbar puncture, visual assessments, detailed headache phenotyping, and MRI-ICP scans to calculate intracranial compliance index at baseline. Following treatment, patients were invited to attend a one-year visit when all assessments were repeated.
resultsThere was significant (p = 0.017) reduction in intracranial compliance index in IIH (mean = 1006.0 cc/mmHg/cm, SD = ± 384.6 cc/mmHg/cm) compared to controls (mean = 1493.0 cc/mmHg/cm, SD = ± 411.8 cc/mmHg/cm), inversely correlating with lumbar puncture opening pressure (r = -0.502, p = 0.029). A significant inverse correlation between compliance index and headache disability was also found (r = -0.458, p = 0.049) and a trend for an association between lower compliance index and increased frequency of headaches (r = -0.430, p = 0.066). This latter became significant (p = 0.018) after accounting for use of analgesics. Following successful treatment, compliance index was increased in all patients at one year (mean of differences = 380.7 cc/mmHg/cm, p = 0.031).
conclusionsThis is the first study to apply the MRI-ICP technique longitudinally in IIH. It illustrates reduced intracranial compliance index in IIH, correlating with opening pressure and headache disability and ameliorating with treatment.
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