Evidence map›Paper›PMID 39857380›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca

Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ignacija VlašićDivision of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0003-3506-5181
Antonio Krstačić-GalićDepartment of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia.
Anđela HorvatDivision of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-5771-2434
Nada OršolićDepartment of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-5102-3606
Anja SadžakDivision of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-9462-8696
Lucija MandićDivision of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-1099-960X
Suzana ŠegotaDivision of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0001-6416-3835
Maja Jazvinšćak JembrekDivision of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-5037-3919

Funding

Croatian Science Foundation IP-2016-06-8415
6 · The paper itself

Abstract

Although commonly appreciated for their anti-oxidative and neuroprotective properties, flavonoids can also exhibit pro-oxidative activity, potentially reducing cell survival, particularly in the presence of metal ions. Disrupted copper homeostasis is a known contributor to neuronal dysfunction through oxidative stress induction. This study investigated the effects of myricitrin (1-20 μg/mL) on copper-induced toxicity (0.5 mM CuSO

Indexed as

apoptosisatomic force microscopyflavonolmetal-induced neurotoxicitypro-oxidative activity

Identifiers

PMID39857380
PMCPMC11763042

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.