Evidence mapPaperPMID 39857389Full record

ReviewAntioxidants (Basel, Switzerland)2025

Antioxidant Properties of Albumin and Diseases Related to Obstetrics and Gynecology.

Kazushi Watanabe, Hiroyuki Kinoshita, Tomohito Okamoto, Kazumasa Sugiura, Shingo Kawashima, Tetsuro Kimura

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazushi WatanabeDepartment of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Aichi 480-1195, Japan.
Hiroyuki KinoshitaDepartment of Dental Anesthesiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8501, Japan.ORCID 0000-0002-2221-7871
Tomohito OkamotoDepartment of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Aichi 480-1195, Japan.
Kazumasa SugiuraDepartment of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Aichi 480-1195, Japan.
Shingo KawashimaDepartments of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Tetsuro KimuraDepartments of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

Funding

JSPS KAKENHI JP21K08949 and JK24K12544
6 · The paper itself

Abstract

Albumin, the most abundant protein, contributes significantly to various physiological processes, indicating its multifunctional properties. It has drawn the attention of scientists and physicians because of its primary role in maintaining osmotic pressure and involvement in transporting numerous small molecules, including hormones, fatty acids, and drugs. A growing body of evidence has recently illustrated an additional aspect of albumin's antioxidant properties. Therefore, based on recent research findings, this review article delves into the molecular and biochemical aspects of albumin's antioxidative capabilities. We highlight the multifaceted significance of proteins in oxidative stress and their relation to pathologies in obstetrics and gynecology. In particular, we focused on preeclampsia, in which oxidative stress is closely involved in the pathogenesis, and renal dysfunction leads to increased albumin excretion into the urine, resulting in hypoalbuminemia. In addition, we discussed the role of albumin in preeclampsia pathogenesis, diagnosis, and patient prognosis. Understanding the antioxidant properties of albumin opens new avenues for therapeutic intervention and sheds light on novel strategies for combating preeclampsia associated with oxidative damage. In this study, we employed the PubMed database to search for articles that assessed the antioxidant properties of albumin, with a specific focus on obstetric diseases, particularly preeclampsia. The last update of the search was conducted in November 2024.

Indexed as

albuminantioxidantpreeclampsia

Identifiers

PMID39857389
PMCPMC11760856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.