Biomonitoring of Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites in Workers at a Waste-to-Energy Incinerator, Turin, Italy.

This paper presents the results of the human biomonitoring of ten urinary OH-PAHs (hydroxylated polycyclic aromatic hydrocarbon) in a cohort of workers at an incinerator in Turin, Italy. Long-term exposure was assessed through repeated measurements at three time points: before the startup (T0), after 1 year (T1), and after 3 years (T2). Paired data were available for 26 subjects, seven administrative workers (AWs) and 19 plant workers (PWs). Short-term exposure was assessed by comparing start-end shift measurements. Due to the non-normal distribution of the data, the nonparametric Cuzick's test for trend and the Wilcoxon signed-rank test for paired samples were used. Neither the trend nor the T0-T2 comparison tests resulted in statistically significant outputs in the two groups (q-value > 0.05), even when controlling for smoking habits. In relation to PWs, some of the metabolites were higher at T2 with respect to T0, but no linear increase was found. Conversely, 1-OH-PYR (ng/g creatinine) showed lower median values at T1 (61.5) and T2 (67) compared to the baseline (151.3). Similarly, short-term comparisons yielded no significant results, with rather overlapping distributions of values. Overall, no significant increases in metabolite levels were detected as a result of occupational exposure in the incinerator workers considered. These findings align with previous results for metals and ambient air measurements.