Evidence map›Paper›PMID 39857986›Full record

ArticleCancers2025

Blockade of LIF and PD-L1 Enhances Chemotherapy in Preclinical PDAC Models.

Jian Ye, Shuyang S Qin, Angela L Hughson, Gary Hannon, Tara G Vrooman, Maggie L Lesch, Sarah L Eckl, Lauren Benoodt, Bradley N Mills, Edith M Lord and 5 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jian YeDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Shuyang S QinDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-2643-7783
Angela L HughsonDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Gary HannonDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0003-1204-0299
Tara G VroomanDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Maggie L LeschDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sarah L EcklDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-4577-2480
Lauren BenoodtGenomic Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-8834-8970
Bradley N MillsDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Edith M LordCenter for Tumor Immunology Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
Brian A BeltDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
David C LinehanDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
Nadia LuheshiOncology R&D, AstraZeneca, Aaron Klug Building, Granta Park, Cambridge CB2 0AA, UK.
Jim EylesOncology R&D, AstraZeneca, Aaron Klug Building, Granta Park, Cambridge CB2 0AA, UK.ORCID 0000-0001-9043-4352
Scott A GerberDepartment of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

Funding

The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Modulating innate immune cells in the tumor microenvironment of pancreas cancer to enhance anti-tumor immunityR01CA168863 · NCI · WASHINGTON UNIVERSITY · PI LINEHAN, DAVID C · 2013 to 2023
$3.6M
Targeting adrenergic stress pathways to Increase tumor sensitivity to radiation and promote development of an anti-tumor immune responseR01CA236390 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GERBER, SCOTT ANDREW, REPASKY, ELIZABETH A · 2019 to 2023
$2.8M
Development of a New Strategy to Treat Locally Advanced Pancreatic CancerR01CA230277 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW · 2019 to 2023
$2.0M
Repolarizing the Tumor and Metastatic Microenvironments to Treat Patients with Pancreatic CancerR01CA262580 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW, LINEHAN, DAVID C · 2021 to 2025
$1.6M
NCI NIH HHS R01 CA168863NCI NIH HHS R01 CA230277NCI NIH HHS R01 CA236390NCI NIH HHS R01 CA262580NIAID NIH HHS T32 AI007285NIH HHS 1R01CA168863-22A9NIH HHS 1R01CA230277-23A4NIH HHS 1R01CA236390-23A5NIH HHS 1R01CA262580-24A3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chemotherapyleukemia inhibitory factor (LIF)pancreatic ductal adenocarcinoma (PDAC)programmed death-ligand 1 (PD-L1)

Identifiers

PMID39857986
PMCPMC11763610

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.