Evidence map›Paper›PMID 39858150›Full record

ArticleAnimals : an open access journal from MDPI2025

Effects of Red Clover Isoflavones on Growth Performance, Immune Function, and Cecal Microflora of Mice.

Rongrong Guo, Xuqin Song, Xiaodie Li, Cheng Zeng, Ying Chen, Chunjie Li, Jian Yang, Deyuan Ou

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongrong GuoDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.
Xuqin SongDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.ORCID 0000-0002-8671-3161
Xiaodie LiDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.
Cheng ZengDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.ORCID 0009-0008-1058-6005
Ying ChenDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.ORCID 0009-0002-8434-0127
Chunjie LiLaboratory of Pulmonary and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, Sichuan University, Chengdu 610000, China.
Jian YangDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.
Deyuan OuDepartment of Veterinary Medicine, College of Animal Science, Guizhou University, Guiyang 550025, China.

Funding

Guizhou Province General Colleges and Universities Youth Science and Technology Talent Growth Project QJH-KY-2022-151Guizhou Provincial Basic Research Program (Natural Science) QKHJC-ZK-2022-129 and QKHJC-ZK-2023-109National Natural Science Foundation of China 32202854
6 · The paper itself

Abstract

Isoflavone components extracted from red clover have anti-inflammatory, antioxidant and immune boosting effects. We hypothesize that red clover isoflavones (RCIs) achieve health-promoting effects via altering the gut microbiota. A total of 48 mice (20 ± 2 g) were randomly divided into a control group, low-dose group (0.05% RCIs in feed), middle-dose group (0.1% RCIs in feed), and high-dose group (0.2% RCIs in feed) with 12 mice per group. The feeding period was 20 d. The results showed that RCIs can increase the daily gain and decrease the ratio of feed to gain in mice. The organ indexes and blood biochemical indexes of the mice in each RCI group were in the normal range, indicating that RCIs do not damage liver or kidney function. RCI supplementation increased serum immunity and altered the microbial community structure in the cecum of the mice. RCIs can increase the diversity of beneficial bacteria such as

Indexed as

blood biochemistrycecal microfloragrowth promotionimmune functionred clover isoflavones

Identifiers

PMID39858150
PMCPMC11758327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.