Evidence map›Paper›PMID 39858433›Full record

ArticleBiomolecules2024

NADH Reductive Stress and Its Correlation with Disease Severity in Leigh Syndrome: A Pilot Study Using Patient Fibroblasts and a Mouse Model.

Tamaki Ishima, Natsuka Kimura, Mizuki Kobayashi, Chika Watanabe, Eriko F Jimbo, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Kei Murayama, Akira Ohtake and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tamaki IshimaDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke 329-0498, Japan.ORCID 0009-0002-2309-265X
Natsuka KimuraDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke 329-0498, Japan.
Mizuki KobayashiDepartment of Pediatrics, Jichi Medical University, Shimotsuke 329-0498, Japan.
Chika WatanabeDepartment of Pediatrics, Jichi Medical University, Shimotsuke 329-0498, Japan.
Eriko F JimboDepartment of Pediatrics, Jichi Medical University, Shimotsuke 329-0498, Japan.
Ryosuke KobayashiBiosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan.ORCID 0009-0009-8666-1312
Takuro HoriiBiosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan.
Izuho HatadaBiosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan.
Kei MurayamaCenter for Medical Genetics, Chiba Children's Hospital, Chiba 266-0007, Japan.
Akira OhtakeDepartment of Clinical Genomics, Faculty of Medicine, Saitama Medical University, Moroyama 350-0495, Japan.ORCID 0000-0003-1147-3113
Ryozo NagaiJichi Medical University, Shimotsuke 329-0498, Japan.
Hitoshi OsakaDepartment of Pediatrics, Jichi Medical University, Shimotsuke 329-0498, Japan.ORCID 0000-0002-1320-1165
Kenichi AizawaDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke 329-0498, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD) is a critical cofactor in mitochondrial energy production. The NADH/NAD

Indexed as

FibroblastsLeigh DiseaseNADAnimalsChildChild, PreschoolDisease Models, AnimalElectron Transport Complex IFemaleHumansMaleMiceMice, KnockoutOxidation-ReductionPilot ProjectsElectron Transport Complex INADNDUFS4 protein, humanNdufs4 protein, mouseLC-MS/MSLeigh syndromemitochondrial diseasesNADHNdufs4-KO micereductive stress

Identifiers

PMID39858433
PMCPMC11764390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.