Evidence map›Paper›PMID 39858610›Full record

ArticleGenes2025

Genome-Wide Insights into Internalizing Symptoms in Admixed Latin American Children.

Gabriela de Sales Guerreiro Britto, Alberto O Moreira, Edson Henrique Bispo Amaral, Daniel Evangelista Santos, Raquel B São Pedro, Thaís M M Barreto, Caroline Alves Feitosa, Darci Neves Dos Santos, Eduardo Tarazona-Santos, Maurício Lima Barreto and 4 more

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gabriela de Sales Guerreiro BrittoInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.ORCID 0000-0001-9853-7284
Alberto O MoreiraInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.
Edson Henrique Bispo AmaralInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.ORCID 0000-0001-5879-9212
Daniel Evangelista SantosInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.
Raquel B São PedroInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.ORCID 0000-0002-2443-321X
Thaís M M BarretoInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.
Caroline Alves FeitosaEscola Bahiana de Medicina e Saúde Pública, Salvador 40295-150, Brazil.
Darci Neves Dos SantosInstituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador 40110-040, Brazil.ORCID 0000-0003-1500-8294
Eduardo Tarazona-SantosDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Maurício Lima BarretoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz, Salvador 41745-715, Brazil.
Camila Alexandrina Viana de FigueiredoInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador 40231-300, Brazil.ORCID 0000-0003-1356-6188
Ryan Dos Santos CostaInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador 40231-300, Brazil.ORCID 0000-0003-3075-0729
Ana Lúcia Brunialti GodardDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-5719-8802
Pablo Rafael Silveira OliveiraInstituto de Biologia, Universidade Federal da Bahia, Salvador 40170-115, Brazil.ORCID 0000-0001-9541-3737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesInternalizing disorders, including depression and anxiety, are major contributors to the global burden of disease. While the genetic architecture of these disorders in adults has been extensively studied, their early-life genetic mechanisms remain underexplored, especially in non-European populations. This study investigated the genetic mechanisms underlying internalizing symptoms in a cohort of Latin American children.

methodsThis study included 1244 Brazilian children whose legal guardians completed the Child Behavior Checklist (CBCL) questionnaire. Genotyping was performed using the Illumina HumanOmni 2.5-8v1 BeadChip.

resultsThe genome-wide association analysis revealed a significant association of rs7196970 (

conclusionsThis study identifies

Indexed as

AnxietyATP-Binding Cassette, Sub-Family C ProteinsDepressionAdolescentBrazilChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLatin AmericaMalePolymorphism, Single NucleotideATP-Binding Cassette, Sub-Family C Proteinsmultidrug resistance-associated protein 1childhoodGWASinternalizing symptomsLatin Americans

Identifiers

PMID39858610
PMCPMC11765437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.