Evidence map›Paper›PMID 39859221›Full record

ArticleInternational journal of molecular sciences2025

Cell Membrane-Integrated Neuroligin-1 Regulates the Anti-Inflammatory Effects of CRC Cell-Derived Exosomes.

Mohammad Mahmoudian, Francesco Trotta, Stefania Raimondo, Federico Bussolino, Marco Arese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad MahmoudianDepartment of Oncology, University of Torino, 10060 Candiolo, Italy.
Francesco TrottaDepartment of Chemistry, University of Torino, 10125 Torino, Italy.
Stefania RaimondoDepartment of Clinical and Biological Sciences, University of Torino, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0002-8907-473X
Federico BussolinoDepartment of Oncology, University of Torino, 10060 Candiolo, Italy.
Marco AreseDepartment of Oncology, University of Torino, 10060 Candiolo, Italy.ORCID 0000-0002-7384-9406

Funding

This work was supported by University of Torino grant AREM_RILO_19_01 - Bando Ricerca Locale 2019 - to M.A, AIRC IG grants # 22910, #12182 # 18652 to F.B; Regione Piemonte A1907A
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) are one of the most abundant cell types in the colorectal cancer (CRC) tumor microenvironment (TME). CRC cell-derived exosomes support macrophage polarization toward an M2-like phenotype, which leads to tumor growth and metastasis. Neuroligin 1 (NLG1) is a transmembrane protein critical in synaptic function. We reported that NLG1 via an autocrine manner promotes CRC progression by modulating the APC/β-catenin pathway. This study aimed to answer whether NLG1 is involved in the exosome-mediated intercellular cross-talk between CRC and TAMs. Our results showed that exosomes of NLG1-expressing CRC cells induce M2-like (CD206

Indexed as

Cell Adhesion Molecules, NeuronalCell MembraneColorectal NeoplasmsExosomesCell Line, TumorHumansMacrophagesNeuroliginsTumor-Associated MacrophagesTumor MicroenvironmentCell Adhesion Molecules, Neuronalneuroligin 1Neuroliginscolorectal cancer cellsexosomemacrophagesNeuroligin-1

Identifiers

PMID39859221
PMCPMC11765187

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.