Evidence mapPaperPMID 39859241Full record

ArticleInternational journal of molecular sciences2025

Anti-Inflammatory and Anti-Fibrotic Effects of a Mixture of Polyphenols Extracted from "Navelina" Orange in Human Hepa-RG and LX-2 Cells Mediated by Cannabinoid Receptor 2.

Ilenia Saponara, Emanuela Aloisio Caruso, Miriam Cofano, Valentina De Nunzio, Giuliano Pinto, Matteo Centonze, Maria Notarnicola

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Potential of Orally Administered Quercetin, Hesperidin, andInternational journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilenia SaponaraLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0009-0008-5909-057X
Emanuela Aloisio CarusoLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0009-0007-2969-5052
Miriam CofanoLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0000-0002-8946-7832
Valentina De NunzioLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0000-0001-7912-9023
Giuliano PintoLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0009-0003-9042-7082
Matteo CentonzeLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.
Maria NotarnicolaLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.ORCID 0000-0003-2274-2198

Funding

Ministero della Salute DDG 851/23
6 · The paper itself

Abstract

Navelina oranges (

Indexed as

Antifibrotic AgentsAnti-Inflammatory AgentsCitrus sinensisHepatocytesPolyphenolsReceptor, Cannabinoid, CB2Cell LineCyclooxygenase 2Hepatic Stellate CellsHumansp38 Mitogen-Activated Protein KinasesPlant ExtractsTransforming Growth Factor betaAntifibrotic AgentsAnti-Inflammatory AgentsCyclooxygenase 2p38 Mitogen-Activated Protein KinasesPlant ExtractsPolyphenolsReceptor, Cannabinoid, CB2Transforming Growth Factor betaCB2RCOX-2fibrosishesperidinliver inflammationNavelina orange extractp38 MAPKTGF-β

Identifiers

PMID39859241
PMCPMC11765147

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.