Evidence map›Paper›PMID 39859529›Full record

ArticleInternational journal of molecular sciences2025

Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.

Chien-Yu Huang, Ren-Hao Xie, Pin-Hsuan Li, Chong-You Chen, Bo-Hong You, Yuan-Chin Sun, Chen-Kai Chou, Yen-Hsiang Chang, Wei-Che Lin, Guan-Yu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chien-Yu HuangDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Ren-Hao XieDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Pin-Hsuan LiInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Chong-You ChenDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Bo-Hong YouInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Yuan-Chin SunInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Chen-Kai ChouDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Yen-Hsiang ChangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.ORCID 0000-0003-4491-0076
Wei-Che LinDivision of Neuroradiology, Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Guan-Yu ChenDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-3443-7943

Funding

Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B)" from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan 113W30305Higher Education Sprout Project of the National Yang Ming Chiao Tung University and MOE, Taiwan 113W020211Higher Education Sprout Project of the National Yang Ming Chiao Tung University and MOE, Taiwan 113W020214Kaohsiung Chang Gung Memorial Hospital CORPG8N0031National Science and Technology Council NSTC112-2321-B-A49-015National Science and Technology Council NSTC 112-2321-B-A49-016National Science and Technology Council NSTC112-2636-E-A49-008-National Science and Technology Council NSTC113-2321-B-A49-021National Science and Technology Council NSTC113-2628-B-A49-008-MY3National Science and Technology Council NSTC113-2823-8-A49-003
6 · The paper itself

Abstract

Bisphenol A (BPA) is a prevalent environmental contaminant found in plastics and known for its endocrine-disrupting properties, posing risks to both human health and the environment. Despite its widespread presence, the impact of BPA on papillary thyroid cancer (PTC) progression, especially under realistic environmental conditions, is not well understood. This study examined the effects of BPA on PTC using a 3D thyroid papillary tumor spheroid model, which better mimicked the complex interactions within human tissues compared to traditional 2D models. Our findings demonstrated that BPA, at environmentally relevant concentrations, could induce significant changes in PTC cells, including a decrease in E-cadherin expression, an increase in vimentin expression, and reduced thyroglobulin (TG) secretion. These changes suggest that BPA exposure may promote epithelial-mesenchymal transition (EMT), enhance invasiveness, and reduce cell differentiation, potentially complicating treatment, including by increasing resistance to radioiodine therapy. This research highlights BPA's hazardous nature as an environmental contaminant and emphasizes the need for advanced in vitro models, like 3D tumor spheroids, to better assess the risks posed by such chemicals. It provides valuable insights into the environmental implications of BPA and its role in thyroid cancer progression, enhancing our understanding of endocrine-disrupting chemicals.

Indexed as

Benzhydryl CompoundsEnvironmental ExposurePhenolsThyroid Cancer, PapillaryThyroid NeoplasmsBisphenol A CompoundsCadherinsCell Line, TumorEndocrine DisruptorsEpithelial-Mesenchymal TransitionHumansNeoplasm InvasivenessSpheroids, CellularThyroglobulinBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCadherinsEndocrine DisruptorsPhenolsThyroglobulin3D cancer spheroidBisphenol A (BPA)endocrine-disrupting chemicals (EDCs)epithelial–mesenchymal transition (EMT)papillary thyroid cancer (PTC)

Identifiers

PMID39859529
PMCPMC11766120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.