Evidence mapPaperPMID 39860077Full record

ReviewMolecules (Basel, Switzerland)2025

Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents.

Domenico Iacopetta, Alessia Catalano, Jessica Ceramella, Annaluisa Mariconda, Assunta D'Amato, Paola Checconi, Stefano Aquaro, Pasquale Longo, Maria Stefania Sinicropi

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Domenico IacopettaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0001-5179-7118
Alessia CatalanoDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona, 4, 70126 Bari, Italy.ORCID 0000-0002-7420-4706
Jessica CeramellaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-1386-3601
Annaluisa MaricondaDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano, 10, 85100 Potenza, Italy.ORCID 0000-0002-9763-838X
Assunta D'AmatoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0001-9246-5523
Paola ChecconiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0001-7518-5730
Stefano AquaroDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi, 1, Blocco 11, Coppito, 67010 L'Aquila, Italy.ORCID 0000-0002-8417-2103
Pasquale LongoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-7685-1093
Maria Stefania SinicropiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-2435-8931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led to its conjugation with Schiff bases, which are interesting scaffolds endowed with diverse biological properties. The resultant chitosan-based Schiff bases (CSBs) are widely studied in scientific literature due to the myriad of activities exerted, both catalytic and biological, including anticancer, anti-inflammatory, antioxidant, and especially antimicrobial ones. Antimicrobial resistance (AMR) is one of the major public health challenges of the twenty-first century because it represents a threat to the prevention and treatment of a growing number of bacterial, parasitic, viral, and fungal infections that are no longer treatable with the available drugs. Thus, in this review, we present a brief outline of the biological activities of CSBs as well as their complexes with metals, with a particular focus on the recent literature regarding the antimicrobial effect of these captivating derivatives.

Indexed as

Anti-Infective AgentsChitosanCoordination ComplexesAnimalsHumansSchiff BasesAnti-Infective AgentsChitosanCoordination ComplexesSchiff Basesantibacterialantifungalantimicrobialchitosanmetal complexesSchiff bases

Identifiers

PMID39860077
PMCPMC11768026

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.