Evidence mapPaperPMID 39860192Full record

ArticleMolecules (Basel, Switzerland)2025

Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine.

Monika Wojtyłko, Ariadna B Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach and 5 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Monika Wojtyłko3D Printing Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0002-2672-6171
Ariadna B NowickaInstitute of Materials Research and Quantum Engineering, The Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, 3 Piotrowo Street, 60-965 Poznań, Poland.ORCID 0000-0002-5482-2427
Anna Froelich3D Printing Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0002-1491-1329
Mirosław SzybowiczInstitute of Materials Research and Quantum Engineering, The Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, 3 Piotrowo Street, 60-965 Poznań, Poland.ORCID 0000-0001-8933-571X
Tobiasz BanaszekInstitute of Materials Research and Quantum Engineering, The Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, 3 Piotrowo Street, 60-965 Poznań, Poland.
Dorota TomczakInstitute of Chemical Technology and Engineering, Poznan University of Technology, 4 Berdychowo Street, 60-965 Poznań, Poland.ORCID 0000-0002-9287-3989
Wiesław KuczkoInstitute of Materials Technology, Faculty of Mechanical Engineering, Poznan University of Technology, 3 Piotrowo Street, 60-965 Poznań, Poland.ORCID 0000-0002-0621-9738
Radosław WichniarekInstitute of Materials Technology, Faculty of Mechanical Engineering, Poznan University of Technology, 3 Piotrowo Street, 60-965 Poznań, Poland.ORCID 0000-0003-0714-7462
Irena BudnikChair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Barbara JadachDivision of Industrial Pharmacy, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Oliwia Kordyl3D Printing Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0001-6139-8276
Antoni BiałekChair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0001-8838-2805
Julia KrysztofiakChair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0002-7158-4870
Tomasz OsmałekChair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.ORCID 0000-0002-6939-2888
Dimitrios A LamprouSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.ORCID 0000-0002-8740-1661

Funding

European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement 778051Ministry of Science and Higher Education of Poland fund for supporting internationally co-financed projects in 2018-2022 3899/H2020/2018/2National Science Centre (NCN) Poland 2021/42/E/NZ7/00125 (ID: 526262)
6 · The paper itself

Abstract

Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its bioavailability and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing the

Indexed as

AcetamidesDrug Delivery SystemsHydrogelsAdministration, CutaneousHumansMicroinjectionsNaphthalenesNeedlesSkinSkin AbsorptionAcetamidesagomelatineHydrogelsNaphthalenesagomelatinecoated microneedleshydrogeltransdermal delivery

Identifiers

PMID39860192
PMCPMC11767663

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.