Unidirectional Polyvinylidene/Copper-Impregnated Nanohydroxyapatite Composite Membrane Prepared by Electrospinning with Piezoelectricity and Biocompatibility for Potential Ligament Repair.

Chih-Hsin Cheng, Wen-Cheng Chen, Wen-Chieh Yang, Sen-Chi Yang, Shih-Ming Liu, Ya-Shun Chen, Jian-Chih Chen

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Chih-Hsin ChengClinical Histopathology Division, Hualien Armed Forces General Hospital, Hualien 970, Taiwan.

Wen-Cheng ChenAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.ORCID 0000-0002-5581-9991

Wen-Chieh YangAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.

Sen-Chi YangAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.

Shih-Ming LiuAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.

Ya-Shun ChenAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.

Jian-Chih ChenAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.ORCID 0000-0002-9582-6029

Funding

Hualien Armed Forces General Hospital HAFG-D-111005 and HAFG-D-112008KMU research project KMUH112-2R54National Science and Technology Council, Taiwan NSTC 111-2314-B-035-002-MY3, 110-2221-E-035-013, 109-2314-B-037-043 and 109-2622-E-035-014-CC2

6 · The paper itself

Abstract

Ligament tears can strongly influence an individual's daily life and ability to engage in physical activities. It is essential to develop artificial scaffolds for ligament repairs in order to effectively restore damaged ligaments. In this experiment, the objective was to evaluate fibrous membranes as scaffolds for ligament repair. These membranes were created through electrospinning using piezoelectric polyvinylidene fluoride (PVDF) composites, which contained 1 wt.% and 3 wt.% of copper-impregnated nanohydroxyapatite (Cu-nHA). The proposed electrospun membrane would feature an aligned fiber structure achieved through high-speed roller stretching, which mimics the properties of biomimetic ligaments. Nanoparticles of Cu-nHA had been composited into PVDF to enhance the pirzoelectric β-phase of the PVDF crystallines. The study assessed the physicochemical properties, antibacterial activity, and biocompatibility of the membranes in vitro. A microstructure analysis revealed that the composite membrane exhibited a bionic structure with aligned fibers resembling human ligaments. The piezoelectric performance of the experimental group containing 3 wt.% Cu-nHA was significantly improved to 25.02 ± 0.68 V/g·m

Indexed as

composite membraneselectrospinningnanoparticlespiezoelectricity

Identifiers

PMID39861257

DOI10.3390/polym17020185

PMCPMC11769023

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.