Evidence map›Paper›PMID 39861468›Full record

ArticleNutrients2025

A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.

Ashwana D Fricker, Kristija Sejane, Mina Desai, Michael W Snyder, Luis Duran, Rachel Mackelprang, Lars Bode, Michael G Ross, Gilberto E Flores

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashwana D FrickerDepartment of Biology, California State University, Northridge, CA 91330, USA.ORCID 0000-0002-3806-7695
Kristija SejaneDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California San Diego, La Jolla, CA 92093, USA.
Mina DesaiThe Lundquist Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.
Michael W SnyderDepartment of Biology, California State University, Northridge, CA 91330, USA.
Luis DuranDepartment of Biology, California State University, Northridge, CA 91330, USA.
Rachel MackelprangDepartment of Biology, California State University, Northridge, CA 91330, USA.ORCID 0000-0002-7213-7415
Lars BodeDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9914-9571
Michael G RossThe Lundquist Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.ORCID 0000-0001-5500-404X
Gilberto E FloresDepartment of Biology, California State University, Northridge, CA 91330, USA.

Funding

NICHD NIH HHS R01 HD099813NICHD NIH HHS R01HD099813NICHD NIH HHS R21 HD104028NICHD NIH HHS R21HD104028NIGMS NIH HHS SC1 GM136546NIGMS NIH HHS SC1GM136546
6 · The paper itself

Abstract

backgroundMaternal obesity may contribute to childhood obesity in a myriad of ways, including through alterations of the infant gut microbiome. For example, maternal obesity may contribute both directly by introducing a dysbiotic microbiome to the infant and indirectly through the altered composition of human milk that fuels the infant gut microbiome. In particular, indigestible human milk oligosaccharides (HMOs) are known to shape the composition of the infant gut microbiome. The goal of this study was to characterize the HMO profiles of normal-weight and overweight mothers and to quantitatively link HMO concentrations to the taxonomic composition and functional potential of the infant gut microbiome.

methodsNormal-weight (BMI = 18.5-24.9;

resultsNeither the HMO profiles nor the infant microbiome composition varied according to maternal BMI status. Taxonomically, the gut microbiota of infants were dominated by typical gut lineages including

conclusionsThese results suggest that the maternal BMI status does not impact the HMO profiles of human milk. However, select HMOs were correlated with specific bacterial taxa, suggesting that the milk composition influences both the taxonomic composition and the functional capacity of the infant gut microbiome.

Indexed as

Breast FeedingGastrointestinal MicrobiomeMilk, HumanOligosaccharidesAdultBacteriaBody Mass IndexCross-Sectional StudiesFecesFemaleHumansInfantMaleOverweightPilot ProjectsRNA, Ribosomal, 16SOligosaccharidesRNA, Ribosomal, 16Shuman milk oligosaccharidesinfantmetagenomemicrobiome

Identifiers

PMID39861468
PMCPMC11768495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.