ArticleNutrients2025
Influence of Dietary Fiber and Polyphenols During Pre-Gestation, Gestation, or Lactation on Intestinal Gene Expression.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Maternal Diet During Pregnancy and Offspring Health: Current Evidence on Dietary Patterns, Microbiota, and Developmental Programming.Nutrients · 2026Review
- Fermented Foods, Functional Nutrition, and Maternal Gut Microbiota During Pregnancy: Molecular Mechanisms and the Maternal-Infant Microbiome Axis.International journal of molecular sciences · 2026Review
- Maternal Extra Virgin Olive Oil Supplementation Enhances Offspring Immune Function: A Preclinical Study.International journal of molecular sciences · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesDiet composition is important for health, especially during critical periods such as pre-gestation (P), gestation (G), or lactation (S), due to its potential impact not only on the mother but on the offspring. The Mediterranean diet includes many healthy foods rich in fiber and/or polyphenols, such as whole grains, fruits, vegetables, beans, and nuts. The present preclinical study assesses the impact of a diet rich in fiber and polyphenols (HFP diet) during one of those three periods (P, G, or S, three weeks each) on the rat gene expression of the small intestine obtained at the end of the lactation period.
methodsThis analysis was performed by the mRNA two step PCR amplification by random primers and poly-T, followed by library generation and HiSeq X-Ten Illumina sequencing (Seqplexing), and further confirmed by Real time PCR and ELISA.
resultsThe results showed a broad number of genes significantly modulated after the HFP diet compared to the reference diet, with a higher number of genes modulated when the supplementing period was closer to the analysis day (S > G > P). Notably, genes involved in immune signaling, intestinal absorption, and cell growth were among those more significantly affected by the HFP dietary intervention. The HFP diet influenced the expression of key genes such as ferritin, fatty acid synthase, apelin, and complement proteins, among others. There was a unique gene modified in all the intervention periods (Family with Sequence Similarity 117 Member A,
conclusionsOverall, in rats, the influence of diet for a three-week period around birth is able to modulate the intestinal gene expression, and consequently, maternal health, which can eventually have an indirect impact on the offspring.
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