Evidence mapPaperPMID 39861887Full record

ReviewViruses2025

Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19.

Abigail Vanderheiden, Michael S Diamond

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Clinical characteristics ofTranslational pediatrics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abigail VanderheidenDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8791-3165

Funding

The Development and Evaluation of Pan-Coronavirus VaccinesP01AI168347 · WASHINGTON UNIVERSITY · 2025 to 2025
$2.7M
NIAID NIH HHS P01 AI168347NIAID NIH HHS R01 AI157155NIH HHS F32 NS128065NIH HHS P01 AI168347NIH HHS R01 AI157155NINDS NIH HHS F32 NS128065
6 · The paper itself

Abstract

Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, as well as discussing the sequelae that warrant continued and intensive research.

Indexed as

COVID-19Disease Models, AnimalAnimalsCricetinaeHumansMicePost-Acute COVID-19 SyndromePrimatesSARS-CoV-2braincoronavirusgastrointestinal tractheartlong COVIDmouse modelspathogenesis

Identifiers

PMID39861887
PMCPMC11768974

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.