Evidence map›Paper›PMID 39862240›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury.

Qiao Liu, Yan Tan, Zhan-Wei Zhang, Wang Tang, Lei Han, Ke-Ping Peng, Ming-Hui Liu, Gui-Xiang Tian

Abstract readReview
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In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiao Liu *Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Yan Tan *Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Zhan-Wei Zhang *Department of Neurosurgery, The First Hospital of Hunan University of Chinese Medicine, 40007, Changsha, China.
Wang TangDepartment of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Lei HanDepartment of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Ke-Ping PengDepartment of Otorhinolaryngology-Head and Neck Surgery, The First Hospital of Hunan University of Chinese Medicine, 40007, Changsha, China.
Ming-Hui LiuDepartment of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Gui-Xiang TianDepartment of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. tianguixiang@csu.edu.cn.

Funding

The National Natural Science Foundation of China 82002397
6 · The paper itself

Abstract

backgroundHyperoxia-induced brain injury is a severe neurological complication that is often accompanied by adverse long-term prognosis. The pathogenesis of hyperoxia-induced brain injury is highly complex, with neuroinflammation playing a crucial role. The activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which plays a pivotal role in regulating and amplifying the inflammatory response, is the pathological core of hyperoxia-induced brain injury. Additionally, astrocytes actively participate in neuroinflammatory responses. However, there is currently no comprehensive overview summarizing the role of astrocytes in hyperoxia-induced brain injury and the NLRP3 signaling pathways in astrocytes.

objectiveThis article aims to provide an overview of studies reported in the literature investigating the pathological role of astrocyte involvement during the inflammatory response in hyperoxia-induced brain injury, the mechanisms of hyperoxia activateing the NLRP3 inflammasome to mediate pyroptosis in astrocytes, and the potential therapeutic effects of drugs targeting the NLRP3 inflammasome to alleviate hyperoxia-induced brain injury.

methodWe searched major databases (including PubMed, Web of Science, and Google Scholar, etc.) for literature encompassing astrocytes, NLRP3 inflammasome, and pyroptosis during hyperoxia-induced brain injury up to Oct 2024. We combined with studies found in the reference lists of the included studies.

conclusionIn this study, we elucidated the transition of function in astrocytes and activation mechanisms under hyperoxic conditions, and we summarized the potential upstream of the trigger involved in NLRP3 inflammasome activation during hyperoxia-induced brain injury, such as ROS and potassium efflux. Furthermore, we described the signaling pathways of the NLRP3 inflammasome and pyroptosis executed by GSDMD and GSDME in astrocytes under hyperoxic conditions. Finally, we summarized the inhibitors targeting the NLRP3 inflammasome in astrocytes to provide new insights for treating hyperoxia-induced brain injury.

Indexed as

AstrocytesBrain InjuriesHyperoxiaInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsHumansInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAstrocytesHyperoxiaHyperoxia-induced brain injuryNLRP3 inflammasomePyroptosis

Identifiers

PMID39862240

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.