Evidence map›Paper›PMID 39862841›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium.

Matthew I Banks, Emily R Dappen, Elie Matar, Benjamin D Hayum, Michael H Sutherland, Bryan M Krause, Hiroto Kawasaki, Robert D Sanders, Kirill V Nourski

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew I BanksDepartment of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA. Electronic address: mibanks@wisc.edu.
Emily R DappenDepartment of Neurosurgery, The University of Iowa, Iowa City, IA 52242, USA.
Elie MatarCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Benjamin D HayumDepartment of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA.
Michael H SutherlandDepartment of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA.
Bryan M KrauseDepartment of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA.
Hiroto KawasakiDepartment of Neurosurgery, The University of Iowa, Iowa City, IA 52242, USA.
Robert D SandersDepartment of Anaesthetics, University of Sydney, Sydney, NSW 2006, Australia.
Kirill V NourskiDepartment of Neurosurgery, The University of Iowa, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA 52242, USA.

Funding

HUMAN AUDITORY CORTEX PHYSIOLOGYR01DC004290 · NIDCD · UNIVERSITY OF IOWA · 2000 to 2025
$4.4M
Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$712k
Mechanisms of Loss, Recovery and Disorders of ConsciousnessR01GM109086 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$594k
NIA NIH HHS R01 AG063849NIDCD NIH HHS R01 DC004290NIGMS NIH HHS R01 GM109086
6 · The paper itself

Abstract

objectives(1) Gain insight into the mechanisms of postoperative delirium (POD). (2) Determine mechanistic overlap with post-ictal delirium (PID). Epilepsy patients undergoing intracranial electrophysiological monitoring can experience both POD and PID, and thus are suitable subjects for these investigations.

methodsPOD was assessed daily after surgery. PID was assessed following seizures. Resting state data were collected following delirium assessments, during a control period, and during sleep. Slow-wave activity (SWA: 1-4 Hz) and resting state functional connectivity were compared between different time points and according to delirium status.

resultsPOD was present in 6 of 20 participants. Post-operatively, SWA was globally elevated in all participants but highest in POD+ participants. POD+ participants exhibited altered functional connectivity compared to POD-. These differences persisted even after resolution of delirium. PID was present in 7 of 15 participants and was predicted by seizures involving prefrontal cortex. PID+ participants exhibited higher post-ictal SWA versus PID-; no differences in functional connectivity were observed. Post-operative and post-ictal SWA was comparable to sleep in some participants.

conclusionsElevated SWA may predispose patients to both post-operative and post-ictal delirium and may indicate overlapping mechanisms. SIGNIFICANCE: Delirium treatments focused on SWA may be most effective for ameliorating cognitive symptoms.

Indexed as

DeliriumPostoperative ComplicationsSeizuresAdultAgedElectrocorticographyElectroencephalographyFemaleHumansMaleMiddle AgedYoung AdultConsciousnessEpilepsyFunctional connectivityNeurosurgerySleepSlow wave activity

Identifiers

PMID39862841
PMCPMC11893240

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.