ArticleTranslational psychiatry2025
Adolescent mice exposed to TBI developed PD-like pathology in middle age.
Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Tao
Abstract read
In one paragraphArticle in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Rong Sha *Department of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China.
Mingzhe Wu *Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, Liaoning, China.
Pengfei Wang *Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, Liaoning, China.
Ziyuan ChenKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, China.
Wei LeiDepartment of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China.
Shimiao WangDepartment of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China.
Shun GongDepartment of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China. gongshunsmmu@foxmail.com.ORCID http://orcid.org/0000-0003-2361-4462 Guobiao LiangDepartment of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China. guobiaoliang@163.com.ORCID http://orcid.org/0009-0007-7138-5648 Yingqun TaoDepartment of Neurosurgery, General Hospital of Northern Theater Command, Postgraduate Training Base of General Hospital of Northern Theater Command of Jinzhou Medical University, Shenyang, Liaoning, China. yingquntao@163.com.ORCID http://orcid.org/0000-0002-2466-1431 Funding
National Natural Science Foundation of China (National Science Foundation of China) 81971793National Natural Science Foundation of China (National Science Foundation of China) 82371894Natural Science Foundation of Liaoning Province (Liaoning Provincial Natural Science Foundation) 2022JH2/101300055Natural Science Foundation of Liaoning Province (Liaoning Provincial Natural Science Foundation) 2022-YGJC-74Natural Science Foundation of Liaoning Province (Liaoning Provincial Natural Science Foundation) 2023JH2/101700104
6 · The paper itselfAbstract
Traumatic brain injury (TBI) is identified as a risk factor for Parkinson's disease (PD), which is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN). However, the precise mechanism by which chronic TBI initiates PD pathogenesis is not yet fully understood. In our present study, we assessed the chronic progression and pathogenesis of PD-like behavior at different intervals in TBI mice. More than half of the mice exhibited PD-like behavior at 6 months post injury. PD-like behavioral dysfunction and pathological changes were aggravated with the injured time extension in chronic phase of TBI. The loss of tyrosine hydroxylase positive (TH
Indexed as
Brain Injuries, TraumaticDopaminergic NeuronsParkinson DiseaseSubstantia Nigraalpha-SynucleinAnimalsDisease Models, AnimalDisease ProgressionDNA-Binding ProteinsMaleMiceMice, Inbred C57BLMicrogliaTyrosine 3-Monooxygenasealpha-SynucleinDNA-Binding ProteinsTyrosine 3-Monooxygenase
Identifiers
PMID39863574
PMCPMC11763066
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