Evidence map›Paper›PMID 39863914›Full record

ArticleParasites & vectors2025

The developmental lipidome of Nippostrongylus brasiliensis.

Tao Wang, Michael G Leeming, Nicholas A Williamson, Tiffany Bouchery, Rory Doolan, Graham Le Gros, Gavin E Reid, Nicola L Harris, Robin B Gasser

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In one paragraph

Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tao WangDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, VIC, 3010, Australia. tao.wang1@unimelb.edu.au.
Michael G LeemingBio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, VIC, 3010, Australia.
Nicholas A WilliamsonBio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, VIC, 3010, Australia.
Tiffany BoucheryDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123, Allschwil, Switzerland.
Rory DoolanDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123, Allschwil, Switzerland.
Graham Le GrosMalaghan Institute of Medical Research, Kelburn, Wellington, 6012, New Zealand.
Gavin E ReidSchool of Chemistry, The University of Melbourne, Parkville, VIC, 3010, Australia.
Nicola L HarrisDepartment of Immunology, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Robin B GasserDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, VIC, 3010, Australia. robinbg@unimelb.edu.au.

Funding

Australian Research Council DP210101500
6 · The paper itself

Abstract

backgroundNippostrongylus brasiliensis-a nematode of rodents-is commonly used as a model to study the immunobiology of parasitic nematodes. It is a member of the Strongylida-a large order of socioeconomically important parasitic nematodes of animals. Lipids are known to play essential roles in nematode biology, influencing cellular membranes, energy storage and/or signalling.

methodsThe present investigation provides a comprehensive, untargeted lipidomic analysis of four developmental stages/sexes (i.e. egg, L3, adult female and adult male stages) of N. brasiliensis utilising liquid chromatography coupled to mass spectrometry.

resultsWe identified 464 lipid species representing 18 lipid classes and revealed distinct stage-specific changes in lipid composition throughout nematode development. Triacylglycerols (TGs) dominated the lipid profile in the egg stage, suggesting a key role for them in energy storage at this early developmental stage. As N. brasiliensis develops, there was a conspicuous transition toward membrane-associated lipids, including glycerophospholipids (e.g. PE and PC) and ether-linked lipids, particularly in adult stages, indicating a shift toward host adaptation and membrane stabilisation.

conclusionsWe provide a comprehensive insight into the lipid composition and abundance of key free-living and parasitic stages of N. brasiliensis. This study provides lipidomic resources to underpin the detailed exploration of lipid biology in this model parasitic nematode.

Indexed as

Lipid MetabolismLipidomicsLipidsNippostrongylusAnimalsChromatography, LiquidFemaleLarvaLife Cycle StagesMaleMass SpectrometryStrongylida InfectionsLipidsAdaptationGastrointestinal nematodeLipidomeLipidsMass spectrometryNippostrongylus brasiliensisRodent

Identifiers

PMID39863914
PMCPMC11762861

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.