Evidence map›Paper›PMID 39863929›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage.

Anders Schlosser, Bartosz Pilecki, Claire Allen, Andrew V Benest, Amy P Lynch, Jing Hua, Nikita Ved, Zoe Blackley, Thomas L Andersen, Dorle Hennig and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Anders SchlosserDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Bartosz PileckiDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Claire AllenCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Andrew V BenestCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Amy P LynchCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Jing HuaCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Nikita VedCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Zoe BlackleyCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Thomas L AndersenMolecular Bone Histology Laboratory, Department of Pathology, Odense University Hospital, 5000 Odense, Denmark; Molecular Bone Histology Laboratory, Research Unit of Pathology, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark; Danish Spatial Imaging Consortium (DanSIC), University of Southern Denmark, 5230 Odense, Denmark.
Dorle HennigDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Jonas H GraversenDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Sören MöllerOPEN - Open Patient Data Explorative Network, Odense University Hospital and Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Sofie SkallerupDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Maria OrmhøjDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Clemens LangeOphtha-Lab, Department of Ophthalmology, St. Franziskus Hospital, 48145 Münster, Germany; Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Hansjürgen T AgostiniEye Center, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Jakob GrauslundDepartment of Ophthalmology, Odense University Hospital, 5000 Odense, Denmark.
Steffen HeegaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark; Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, 2600 Glostrup, Denmark.
Ivanka DachevaDepartment of Ophthalmology, University of Heidelberg, 69047 Heidelberg, Germany.
Michael KossDepartment of Ophthalmology, University of Heidelberg, 69047 Heidelberg, Germany.
Wenzheng HuVirscio, Inc., 5 Science Park, New Haven, CT 06511, USA.
Bibiana IglesiasVirscio, Inc., 5 Science Park, New Haven, CT 06511, USA.
Matthew S LawrenceVirscio, Inc., 5 Science Park, New Haven, CT 06511, USA.
Hans Christian BeckDepartment of Clinical Biochemistry, Odense University Hospital, 5000 Odense, Denmark.
Lasse Bach SteffensenDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
Nick S LaursenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Gregers R AndersenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Uffe HolmskovDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.
David O BatesCancer Biology, Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2UH, UK.
Grith L SorensenDepartment of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark. Electronic address: glsorensen@health.sdu.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neovascular age-related macular degeneration and diabetic macular edema are leading causes of vision loss evoked by retinal neovascularization and vascular leakage. The glycoprotein microfibrillar-associated protein 4 (MFAP4) is an integrin α

Indexed as

Extracellular Matrix ProteinsRetinal NeovascularizationAnimalsCapillary PermeabilityCell MovementChoroidal NeovascularizationDisease Models, AnimalEndothelial CellsHumansMiceExtracellular Matrix Proteinsdiabetic macular edemaDMEextracellular matrixglycoproteinintegrinMFAP4microfibrillar-associated protein 4nAMDneovascular age-related macular degenerationtherapeutic antibodyvascular leakagex-ray crystallography

Identifiers

PMID39863929
PMCPMC11897753

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.