Evidence map›Paper›PMID 39864601›Full record

ArticleMagnetic resonance imaging2025

Diffusion-weighted arterial spin labeling MRI to investigate mannitol-induced blood brain barrier disruption.

Yash Vardhan Tiwari, Eric R Muir, Zhao Jiang, Tim Q Duong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yash Vardhan TiwariDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Eric R MuirDepartment of Radiology, University of North Carolina, Chapel Hill, NC, USA.
Zhao JiangDepartment of Radiology, Stony Brook University, Stony Brook, NY, USA.
Tim Q DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address: tim.duong@einsteinmed.edu.

Funding

Stroke Imaging of Conscious RatsR01NS045879 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DUONG, TIMOTHY Q. · 2004 to 2014
$3.1M
MRI Study of Hydrogen Water and Minocycline Combination Therapy for Ischemic StrokeR01NS129936 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Timothy Q. Duong, Eric Raymond Muir · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS045879NINDS NIH HHS R01 NS129936
6 · The paper itself

Abstract

purposeDiffusion-weighted arterial spin labeling (DW-ASL) MRI has been proposed to determine the rate of water exchange (K

methodsDW-ASL was measured using a multiple b-value MRI protocol in normal rats at three post-labeling delays (N = 19), before and after intra-carotid injection of mannitol to disrupt BBB in one hemisphere (N = 13). An approach using only two b-values to detect mannitol-induced changes was also tested. DCE MRI and Evans blue histology were performed on the same animals. Quantitative analysis and pixel-by-pixel correlation were performed amongst K

resultsK

conclusionK

Indexed as

Blood-Brain BarrierDiffusion Magnetic Resonance ImagingMannitolAnimalsBrainContrast MediaEvans BlueMaleRatsRats, Sprague-DawleyReproducibility of ResultsSpin LabelsContrast MediaEvans BlueMannitolSpin LabelsArterial spin labelingBlood brain barrierDiffusionDynamic contrast enhanced MRIEvans blueMannitolPerfusion imagingRats

Identifiers

PMID39864601
PMCPMC12742324

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.